Qing Kai Ling Injection Treatment Of Active Rheumatoid Arthritis In Clinical And Experimental Research

Objective: To explore the mechanism of Qingkailing injection (QKLI) in treating rheumatiod arthritis(RA) in active stage. Methods: Seventy cases of RA in active stage were divided into the treated group (38 cases treated with QKLI) and the control group(32 cases treated with HuoBaHuaGen tablet). The syptonis-. signs and laboratory examinations of all patients before and after treatment were observed. In experiment study,severity of arthritis and the arthritic index were investigated in the wister rats with collagen-induced arthritis (CIA) and in mice. In addition, observation of antifebric effect on rabbits was also made.Results: The total effective rate was 89.47 % in treatment group,while in control group,it was 87.5 %. The difference of total effective rate between the two groups was unremarkable (P>O.05), while QKLI is superior to HuoBafluaGen tablet in effect of antifebric. Experiments on animals showed QKLI has the function of antifebric~ dephlogisticate -~ anigesia and immune regulation. I[Iistopthology showed that less synovium hyperplasia and fewer infiltration of inflammatory cells in the group treated with QKLI than the control group. Conclusion:QKLI can be applied to the therapy of RA in. active stage.