Clinical And Experimental Research To Explore Mechanisms Of Zishentongguan Capsules In The Treatment Of Kidney Deficiency And Dampness-Heat Dysuria

Objective:Zishen customs observed deficiency of the kidney capsule of damp-heat treatment of the role of water permits to evaluate the efficacy of animal experiments, the capsule Zishen pharmacodynamics clearance study to examine its treatment of certificates may be leaching mechanism. Capsule Zishen clearance for the new drug development in clinical and experimental foundation.Methods:Sub-theory of this study, clinical and experimental study of three parts. Theoretical research in order to organize the collection of water in ancient and modern evidence documented literature on the main urinary tract infection. Clinical studies to Zishen clearance deficiency of the kidney capsule in the treatment of 40 cases of patients with damp-heat leaching was observed after treatment efficacy, symptom score changes and the main effect of target changes in the laboratory to evaluate its clinical efficacy. Experimental study on the use of non-ligation of the ureter, bladder direct injection method of producing Escherichia coli in rat model of acute pyelonephritis, the preparation of a customs Zishen pills, capsules Zishen customs, customs clearance Zishen a series of drugs, such as soft gelatin capsules. To SD rats were randomly divided into 6 groups: sham operation group, model group, group Zishen pill clearance, customs clearance Zishen capsule group, Zishen clearance high dose capsule, soft capsule Zishen group clearance. Gavage, respectively, the corresponding drug, sham-operated group, model group, such as the volume of normal saline gavage. Separately the first three days in the experiment, 7 days, 12 days to collect samples, evaluate the target by detecting the relevant customs Zishen capsules efficacy, and then to explore its possible role in the treatment of leaching mechanisms permit.Results:Our study shows that: Kidney Bladder hot water are the basic causes of disease card machines, machines for the disease due to the legislation of Yishen Kiyotoshi leaching method for the treatment of the basic law of evidence, which is the legislative basis Zishen pills, which function . Clinical research to suggest that the use of capsule in the treatment of Kidney Kidney clearance certificate leaching damp-heat total effective rate was 87.5%, symptom score decreased significantly than that before treatment, after treatment of urinary interleukin qualitative, quantitative and pre-treatment significantly different than both (P <0.01 ). Experimental results show that: Zishen capsules clearance with anti-inflammatory role of inhibition of urinary tract infection must have a therapeutic effect; and Zishen pill clearance compared to the same dose, the capsules more effective than pills. Conclusion:Zishen studies have shown deficiency of the kidney capsule in the treatment of customs clearance permit effective damp-heat water, and can improve the patient's clinical symptoms, improve quality of life, significantly reduced urinary leukocytes. Its mechanism may be related to the promotion of sIgA secretion urethral mucosa enhance the bactericidal capacity, improve the immune capacity.