The Effect Of Bimin Tablet On ICAM-1 And VCAM-1 Expression In Nasal Mucosa Of Exprimental Allergic Rhinitis

Objectove:TO investigate the effect of Bimin Tablet(BMT) on ICAM-1 (Intercellular adhesion molecule-1) and VCAM-1(Vascular cell adhesion molecule-1) expression in nasal mucosa of experimental allergic rhinitis.Method:SD rats(n=40) were immunized by intraperitoneal injection of 03mg Ovalbumin(OVA)(1ml OVA-AL[OH]₃-saline suspension) q.o.d.Normal group rats(n-16) were treated with the same methods expect injecting OVA.15^th day,20μl of saline containing 20mg of OVA was instilled into nasal cavity for 7consecutive days.Normal group followed by intranasal administration only with saline.The rats challenged into allergic rhinitis(n=40) were randomly divided into four group:allergic rhinitis model group(n=10);the higher dose group of BMT(n=10);the lower dose group of BMT (n=10);Kairuitan treated group(n=10).All animals were treated for 15 days. The nasal mucosa of them were studied by immunohistochemical staining to observe the ICAM-1 and VCAM-1 expression. Result:1.Animal model of allergic rhinitis was established by using ovalbumin intraperitoneal immunization and nasal chanllenge.2.The number of positive immunoreactive cells(ICAM-1 and VCAM-1) was increased significantly in all the groups compared with normal group(P＜0.01).ICAM-1 expression was inhibited by giving with Bimin Tablet and Kairuitan comparedwith allergic rhinitis model group(P＜0.01); VCAM-1 expression was inhibited by giving with Bimin Tablet(especially in the higher dose group of BMT) and Kairuitan comparedwith allergic rhinitis model group(P＜0.01).Conclusion:Bimin Tablet can decrease the expression of ICAM-1 and VCAM-1 in nasal mucosa of experimental allergic rhinitis.