Bimin Shuang Capsule On Allergic Rhinitis Model Th1 / Th2 Cytokine Expression

Objective:To observe the Bimin cool capsule changes in a guinea pig model ofsymptoms of allergic rhinitis, Th1/Th2cells mainly cytokines IL-2, IFN-gamma,IL-4,5levels of IL-impact.Method:Sixty healthy guineaa pigs were randomly pick out fifty,Establish allergicrhinitis guinea pig model,30mg albumin (egg) antigen, adjuvant aluminumhydroxide powder3g as a sensitizing factor used to prepare AR model in guineapigs.the rest of ten as bank control group. Fifty AR model randomly divided into5groups.Bimin cool capsules was used to intervene with the modeling guinea pigs for15days,with Prednisone acetate taken as the controlling group.By the end ofexperimental period, serum sample were take from the animals in each group to thedetermination of guinea pigs IL-2, IFN-gamma, IL-4,5levels.Results:The expression level of Th1(IL-2, IFN-gamma) and the ratio of Th1/Th2inallergic rhinitis guinea pig decreased than normal.Th2(IL4, IL5) expression wassignificantly increased.Bimin cool capsules and prednisone can make Th1expressionlevels in serum, and Th1/Th2ratio of AR guinea pigs increased,the expression of Th2droppedsignificantly.Conclusion:Bimin cool capsuleregulate serum Th1/Th2balance of allergic rhinitis inguinea pigs by reduce the Th2and raise the level of Th1expression to achieve thetreatment of nasal T cell mediated nonspecific inflammation.