Effects Of Dingxuanheji On Plasma The TXA₂/6-K-PGI₂ And The EQ, GLU, GABA Of Brain Tissue Of Vertebro-basilar Artery Insufficiency Model Rabbits

Objective:Clinical observation and animal experiments,observation DingXuan Heji of vertebral - basilar artery insufficiency(VBI) of the efficacy of vertigo,and to explore its mechanism.Methods:bruising blue rabbit vertebrobasilar insufficiency model, observed after administration DingXuan Heji effects of their vertigo. Observation Dingxuan VBI model mixture on rabbit platelet aggregation Lan bruising and plasma TXB₂,6-Keto-PGF and model the impact of rabbit EQ,brain excitatory amino acids - glutamic acid(Glu) and inhibitory amino acid-γ-aminobutyric acid(GABA) content.Results:Compared with model group,DingXuan Heji model can be significantly inhibited rabbit platelet aggregation,blood viscosity significantly improved,while reducing TXB₂,increased 6-keto-PGFla level adjustment TXB₂and 6-keto-PGFla ratio to prevent thrombosis.Can also be effective to reduce bruising blue rabbit VBI model EQ,reduce the content of Glu and GABA content.Conclusion:DingXuan Heji with cerebral protection,the brain may be related to anti-protective effects of excitotoxicity-related injury.Also can reduce blood viscosity,improve blood flow to prevent thrombosis,lower blood lipids,blood sugar,improve microcirculation,increase the role of cerebral blood flow.