Effects Of Xi Mei Ning On Blood Lipid,Hemorrheology And TNF-α Of Diabetic Hyperlipidemia Mice Model

Objective:to study the effects of Ximeining on blood lipid and the tumor necrosis factorα(tumor necrosis factor-α,TNF-α)in serum of DM mice with hyperlipoidemia,and investigate its mechanism.Methods:80 male mice were randomly divided into two groups, the blank and the diabetes.The blank group were fed with normal diet, diabetes group were fed with high sugar and high fat.After eight weeks,the diabetes group was injected with low-dose streptozotocin (STZ),and was damaged parts of the pancreas,so as to induce high blood sugar.One week later we measure blood glucose,fasting plasma glucose(FBG)＞16.7mmol / L were carried into the model of successful experiments.The diabetes will be divided into the model of diabetic mice,the ximeining group,and the xuezhikang group. With saline garage to blank and model group mice,the ximeining group and the Xuezhikang group treatment by different weight to adult dose of 0.018 times the corresponding administration.By the end of the 14th week,we kill the animals by picking the overnight fasting blood eyeball,collecte the blood with different sub-tube,and separate the serum to determinate the level of glucose,glycated hemoglobin,serum insulin,blood lipids,hemorrheolog and TNF-α.Results:With high sugar and high fat diet + STZ integrated model of the mice model of their blood sugar,blood lipid, hemorrheolog and TNF-αlevels were significantly higher than the control group;With the ximeining group their blood sugar,blood lipid,hemorrheolog and TNF-αlevel were significantly lower compared with the model;Blood sugar and TNF-αlevels of ximeining group were lower than xuezhikang treatment group,it is statistically significant;blood lipid levels of ximingning group decreases compared with xuezhikang group,it is statistically significant.Conclusion:High sugar and high fat diet + STZ integrated model of successful replication of diabetic hyperlipidemia in the model;ximeining lipid metabolism of diabetic mice disorder of the blood sugar,blood lipid,hemorrheolog and TNF-αtreatment of a significant role,One of the mechanisms on the effects may achieve the over-expression by inhibiting TNF-α...