Effects Of Xi Mei Ning On Blood Lipid,Hemorrheology And Leptin In Blood Serum Of Diabetic Hyperlipi Demia Rat Model

Objective.To study the effects of Ximeining on blood lipid,hemorrheology and Leptin in serum of 2DM mice with hyperlipoidemia,and investigate its mechanism.Methods:80 male rats were randomly divided into two groups,the blank group and diabetes group.To the control group fed normal diet,diabetes group high sugar and high fat diet.After eight weeks,the diabetes group was injected with low-dose streptozotocin(STZ),damaged part of the pancreas,induced by high blood sugar.One week later measure blood glucose,fasting plasma glucose(FBG)>16.7mmol/L,which were choosed into the model for successful experiments.Experimental diabetes will be divided into the model of diabetic rats,the XIMEINING group,and the XUEZHIKANG group.With saline gavage to blank and model group mice,the XIMEINING group and the XUEZHIKANG group treatment by different weight to adult dose of 0.018 times the corresponding administration.After 14 weekends administration,kill the animals by picking the overnight fasting blood eyeball,collecting the blood with different sub-tube,separating the serum,to determinate the level of glucose, glycated hemoglobin,serum insulin,blood lipids,hemorrheolog and Leptin.Results:With high sugar and high fat diet + STZ integrated model of the mice model of their blood sugar,blood lipid,hemorrheolog and Leptin.Levels were significantly higher than the control group.With the ximeining group their blood sugar,blood lipid,hemorrheolog and TNF-αlevel compered with the model were significantly lower,Blood sugar and Leptin levels of XIMEINING group were lower than xuezhikang treatment group.It was statistically significant,blood lipid levels of XIMEINING group decreased compared with XUEZHIKANG group.It was statistically significant.Conclusion:High sugar and high fat diet + STZ integrated model of successful replication of diabetic hyperlipidemia in the modeI,XIMEINING lipid metabolism of diabetic mice disorder of the blood sugar,blood lipid, hemorrheolog and Leptin treatment of a significant role.It's role is imposible one of the mechanisms by inhibiting Leptin to achieve the over-expression.