Clinical Research On Gonging Granules Treating Endometrorrhagia Caused By IUD-wearing And Observe The Influence To The Uterus Vessel Construct Of The Rats

Objective:To investigate the clinical curative effect and mechanism of Gongning granules in treating patients with Endometrorrhagia caused by IUD-wearing diagnosed combination of stasis and heat syndrome. Methods:1.Clinical Study Bring into 119 cases of suffers altogether, 99 cases of them belong to combination of stasis and heat syndrome of Endometrorrhagia caused by IUD-wearing diagnosed (divided into Indomethacin treatment group with 49 cases of suffers and Gongning granules treatment group with 50 cases of suffers, both treated 1 course of treatment), 20 cases of them belong to blank comparison group without IUD contraception and menstruating normally. Observe total curative effect, herbalist doctor syndromes and endometrial histology changes. 2. The animal experiment All the rats for the experiment were divided into 7 groups:the pseudo-operative group,the IUD-insert model group,the high dose group of Gongning granules,the middle dose group of Gongning granules,the low dose group of Gongning granules,Indomethacin granules control group,the normal group , each group having 8 rats. Observe the influence of Gongning granules to the uterus vessel construct of the rats. Results:1.The rate of total curative effect which treatment group treated the patients with Endometrorrhagia caused by IUD-wearing diagnosed combination of stasis and heat syndrome was 90.00%,and the rate of total curative effect of the control group was 71.42%,the two groups were different(p<0.05). 2. In improving the TCM symptom ,The rate of effect which Gongning granules group was 94.00%,and the indomethacin group was 65.31%, the two groups were different(p<0.01). 3. In regualting menstruation, The rate of effect which Gongning granules group was 94.00%,and the indomethacin group was 77.55%, the two groups were different(p<0.05). 4.Gongning granules could improve superficial capillary vessel anapetia of Endometria, endothelial cell degeneration, basal membrane unintegrity and vessel wall disrupt,could decrease thromb, improve arteriae helicinae broaden and arrange derangement of contractile fiber cells. 5. Gongning Granules could obviously improve the abnormal transform of Endometrial angioarchitecture of IUD-wearing rats. Conclusion: Gongning Granules has great effect in treating Endometrorrhagia caused by IUD-wearing diagnosed combination of stasis and heat syndrome,can protect and restoring Endometrial blood vessel harm of Endometrorrhagia caused by IUD-wearing diagnosed , could obviously improve the abnormal transform of Endometrial angioarchitecture of IUD-wearing rats.