Binary Logistic Regression Analysis On Pathogenetic Risk Factors Of Psoriasis Of Wind-heat And Blood Dryness Type

Psoriasis is a common recrudescent chronic inflammatory dermatosis. In traditional Chinese medicine (TCM) , wind-heat and blood dryness is a common type. The pathogenetic risk factors of it are very complicated. Scholars of domestic and overseas have made many studies. Though they haven' t made a certain conclusion, they found the under possible pathogenetic risk factors: heredity, infection, dysmetabolism, immunity, endocrine, mental stress, medicine, diet, trauma, environment, etc. TCM indicates that psoriasis is the integrated result of the six exogenous factors, the seven emotional factors, improper diet, overstrain, stress and lack of physical exercise and so on. Modern medicine has made many studies on the pathogenetic risk factors of psoriasis, but there hasn' t any reports about the pathogenetic risk factors of psoriasis of wind-heat and blood dryness type. For that vacuity, this study tries to make an investigation on it.Objective: To explore the pathogenetic risk factors of psoriasis of wind-heatand blood dryness type and thereby to provide favourable reference datas forits prevention and cure.Methods: 55 patients with psoriasis, together with 55 normal controls wereinvestigated through questionnaires. The 1: 1 matched case-control study wasconducted. A binary logistic regression model was used. SPSS 13.0 was appliedfor data analysis.Results: ? Statistical results of age of onset: The distribution of age ofonset is 16~39 years old. Cuj. cujus 18~39 years old for the males, while16~36 years old for the females, which matches the literature. The mean ageof onset is (25.76 + 5.764) years old. Cuj. cujus (26.97±5. 169) years oldfor the males, while (24.32 + 6.203) years old for the females. There' s no significant difference between them (t = 1.726, P>0. 05) . To divide the cases into two groups by with and without family history, there' s no significant difference between their mean age of onset either. (t=0. 389, P>0. 05) . (D Statistical results of the pathogenetic risk factors: In the case group, the masculine rates of heredity and infection are maximal, 25.5% and 18.2% respectively. And to make a Chi-square test of paired comparison of enumeration data with the normal control group, their X2 values are higher with P<0.05. That indicates that they are the pathogenetic risk factors of psoriasis of wind-heat and blood dryness type. Moreover, Heredity entered the final binary logistic regression equation, which shows it' s certainly one of the pathogenetic risk factors and that its influence is the most obvious. The X2 values of endocrine, mental stress, medicine, diet, exposure to damp, chemical stimulus and environment factors are lower with P<0. 05 and the P values of their OR value are higher than 0. 05. That expresses they are not the pathogenetic risk factors. Nevertheless, in the case group, the masculine rates of mental stress and diet are 14. 5% and 12. 7% respectively, while 10. 9 % for exposure to damp with 0R=7. 821. These numerical datas indicates simultaneously that, even though their X2 values are lower with P>0. 05, if the sample is enlarged their differences between the groups, among the factors and various levels would be expressed more evidently and that there would be positive results. Nevertheless, as our society grows more and more developed and prosperous, mental stress and diet factors have become very common in healthy crowd. Therefore, even if the sample is enlarged, the statistical results would still show that they are not the pathogenetic risk factors of psoriasis of wind-heat and blood dryness type or their risks would be lower. The B value of endocrine is -1.014 with 0R=0. 363, which indicates it may be a protective factor. But P>0. 05, that shows endocrine may be a confounding factor.Conclusions: Heredity and infection factors are both the pathogenetic risk factors of psoriasis of wind-heat and blood dryness type and the former may play a most important role in the onset. Endocrine, mental stress, medicine, diet, exposure to damp, chemical stimulus and environment factors are not the pathogenetic risk factors. However, mental stress, diet and exposure to damp may get positive results if the sample is enlarged. Meanwhile, endocrine wasdemonstrated to be a confounding factor.