Experimental Research Of Liushen Pill And Liushen Decoction On The Inducing Of Tumor Cell Withering

From the angle of molecular biology the pathologic mechanism of malignant hyperplasia and the methods of suppressing tumor formation were introduced. The theoretical foundation and the fundamentals of pharmacology of the induction of cell withering that was the key to suppress tumor were expounded. Some Chinese herbs and formula made with herbs have effects of injuring DNA, suppressing topology amylase, anti-metabolism, hormone and inducing cell differentiation, which give scientific foundation for inducing cell to wither with Chinese herbs.According to TCM concept of wholism, tumor formation is due to the interaction between normal tumor precursor cells and the inner circumstance in human body that also effect on the existence and development of tumor, and canceration course is a potentially reversible course. Traditional Chinese medicine can indirectly adjust the existence and development of whole bodycells including tumor cell through adjusting the inner circumstance in the body.For the above-mentioned reasons, the experimental study of Liushen pill and Liujunzi decoction suppressing tumor and inducing tumor cell to wither was established, which including two parts of in vitro and in vivo to expound effectual mechanism of the two formulas and the relation between them and tumor cell withering.The results showed that both of the two formulas have effects on suppressing tumor. The main effect on mice carried with tumor of Liushen pill is to eliminate the pathogenic factor, which has a high rate of inducing tumor cell to wither. The withering rate for 48h of mice serum with 20% content of Liushen pill is 13.22%. Maybe, it is related to the effects of three drugs, Moschus, Verenum Bufonis and Borneolum, which suppress toxic substance secreted from tumor to injure body. Some drugs strengthening the body resistance should be used as Liushen pill associated with chemical therapy to treat tumor. The main effect on mice carried with tumor of Liujunzi decoction is to strengthen the body resistance, which has a less rate of inducing tumor cell to wither than that of Liushen pill. But Liujunzi decoction has a good effect on putting on weight of mice and ordinary physical condition of mice was better than those with Liushen pill. It implied that the two formulas coule improve body immunologic function to induce tumor cell to wither, especially to immune response in cellular immunity.