| Irritable bowel syndrome (IBS) is a common functional disease. It is not a threat to our human lives. IBS has high morbidity, high rate of relapse. Its symptoms are outstanding. It can cause heavy mental stress and economic burden. Modern medicine is lack of satisfactory treatment. Thus IBS has aroused more and more attention by the medical profession. Tradional Chinese medicine has good curative effect of treating irritable bowel syndrome. It can Relieve symptoms and has less adverse reaction. Tradional Chinese medicine has more advantages in IBS.Literature Review:This part summarized the modern medicine and traditional Chinese medicine researchs and developments about irritable bowel syndrome-diarrhea(IBS-D) in recent years. Modern medicine part includes the epidemiology, pathogenesis and treatment progress about IBS-D. Traditional Chinese medicine part introduces the progress of names, etiology and pathogenesis, clinical classification and treatment about IBS-D. They are the basis of researching traditional Chinese medicine treatment of IBS-D.Clinical research:[Objective] To observe and evaluate the clinical curative effect, anxiety or depression of using Wen Shen Jian Pi soup to treat spleen yang deficiency and kidney yang deficiency type IBS-D.[Method] This research was based on 66 cases of outpatients from Wang Jing Hospital during February 2014-February 2015 who conform to the RomeⅢ diagnostic criteria and also conform to the Spleen Yang-deficiency and Kidney Yang-deficiency of TCM. Using a random number table to randomly divide them into treatment group and control group. These two groups each had 1 case falling off. There were 64 cases participating in statistics. Each group had 32 cases. Patients’age, gender, the score of IBS-SSS before treatment, TCM syndrome integral and the Hospital Anxiety and Depression Scale had no statistical significance(P>0.05). Treatment group were treated with Wen Shen Jian Pi Soup,which were Boiled for 150ml and were drinked before breakfast and sleeping. The control group ware treated with maleic acid trimebutine capsule, which were 200mg each time,30minutes before breakfast, lunch and dinner. The courses of treatment were both 4 weeks.[Results]Disease curative effect comparison:In the treatment group (32 cases), 13 cases recovered,6 cases were markedly effective and 11 cases improved. The total effective rate was 93.8%. In the control group(32 cases),3 cases recovered,7 cases were markedly effective and 16 cases improved. The total effective rate was 81.3%. Difference between the treatment group and the control group was not statistically significant. TCM syndrome curative effect comparison: In the treatment group,3 patients recovered,17 cases were markedly effective and 10 cases were effective, the total effective rate was 93.8%. In the control group.no one recovered,2 cases were markedly effective and 20 patients improved. The total effective rate was 73.3%. The treatment group is better than the control group(P=0.01). After treatment, the results of irritable bowel syndrome severity score(IBS-SSS) with the treatment group is better than that with the control group(P＜0.05). About the change of the degree of abdominal pain, abdominal time, degree of abdominal distention individual scores, the treatment group and the control group has not got significant difference(P＞0.05). About the total integral of TCM syndromes, the treatment group is better than that of control group(P＜0.001). About improvement of the diarrhea,extreme chilliness.waist and knee pain, bowel and break wind, loss of appetite and languid,the treatment group is superior to the control group(P＜0.05). For the improvement of anxiety and depression, the treatment group is also better than that of control group(P＜0.05).[Conclusion] Wen Shen Jian Pi Soup has obvious therapeutic effect for treating Spleen Yang-deficiency and Kidney Yang-deficiency syndrome of IBS-D. It can significantly improve the major clinical manifestations,TCM syndrome manifestations and anxiety or depression symptoms of patients.
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