Analysis Of The Clinical Significance On The Correlation Between Serum Uric Acid Level And Condition And Cognitive Dysfunction In Parkinson’s Disease

Objective: The purpose of this study is to observe the serum uric acid levels in patients with Parkinson’s disease,to analyze the relationship between serum uric acid level and different Hoehn-Yahr(H-Y)classifications,and to explore the connection of uric acid and cognitive impairment in Parkinson’s disease.Methods: Fifty patients,27 males and 23 females with Parkinson’s disease who are reveived by neurology department at first in Hospital of Hebei North University without anti-parkinson treatment are selected as the research group.Fifty physical examinees of the same period,26 males and 24 females in hospital of Hebei North University are selected as the control group.Fasting morning serum uric acid levels in the research group and control group are measured respectively.Compare the 2 groups’ serum uric acid levels and analyse the difference.The research group are divided into 3 groups based on Hoehn-Yahr(H-Y)hierarchical,10 cases of mild group,moderate group 30 cases,10 cases of severe group,Fifty physical examinees are treated as control group.The Plasma uric acid level is compared in each group.Meanwhile,their relationship with different Hoehn-Yahr(H-Y)classification is analyzed.According to the Chinese version of Montreal cognitive assessment scale(MOCA),there are 32 patients with normal cognitive function and 18 cases in the cognitive dysfunction group.Fifty physical examinees are treated as control group.The serum uric acid level in patients is compared and the relationship with cognitive impairment is analyzed.All statistical analyzes are performed with SPSS version 17.0.Results: Comparison of general clinical data: The difference is not statistically significant(P>0.05)between the research group and the control group: age,gender,educational years.Serum uric acid value comparison between research group and control group: the research group is(285.37±56.78)μmol/L,while the control group is(339.50±96.43)μmol/L.the serum uric acid level in research group is significantly lower than those in control group,differences are statistically significant,(P<0.05).The serum uric acid level in the mild,moderate and severe groups are lower than those of control group,the above differences are statistically significant(P<0.05).There is no significant difference in serum uric acid level between mild,moderate and severe groups(P>0.05).Comparison of serum uric acid level between cognitive dysfunction group,normal cognitive function group and control group: the cognitive dysfunction group is averaged(255.02±85.23)μmol/L,and the normal cognitive function group is on average(302.44±49.01)μmol/L.the average of control group is(339.50±96.43)μmol/L.Serum uric acid level in the control group is higher than those in other groups.In addition,the group of cognitive dysfunction is less than those of the normal cognitive function group,which is statistically significant for the above differences(P<0.05).Conclusions: 1 The decrease of serum uric acid is associated with Parkinson’s disease.2 There is no correlation between serum uric acid level and H-Y disease grade of Parkinson’s disease.3 The decrease of uric acid level is related with cognitive dysfunction in Parkinson’s disease patients.