| Objective:The aim of this study was to study the effects and comparison of different moxibustion methods (medicated moxa stick, mild-warm moxibustion and wheat-grain cone moxibustion) on side effects of cancer chemotherapy, and to observe the effect of bone marrow suppression, gastrointestinal tract symptoms, immune system and quality of life in cancer patients who treated with chemotherapy, to provide clinical evidence data in clinical cancer chemotherapy provide clinical basis for the popularization and application.Method:All of the 120 cases were diagnosed as malignant tumor in the oncology department, Jiangsu Province Hospital of Traditional Chinese Medicine and Jiangsu Province Hospital of integrated traditional Chinese and Western medicine hospital, were randomly divided into treatment groups and control group, after eliminating loss cases, medicated moxa stick treatment group 26 cases, mild-warm moxibustion treatment group 26 cases, wheat-grain cone moxibustion treatment group 32 cases and control group 27cases. All groups of patients are treated with western medicine routine chemotherapy regimens, for treatment groups are combined with moxibustion therapy on Ihe main point:Guanyuan (REN4), Shenque (REN8), Zusanli (ST36) (bilateral),15mins per 1 acupoint, patients were given treatment once a day, six times per week. All groups were observed for 3 cycles of chemotherapy (1 cycle duration long about 3 weeks). The observation index of all groups were recorded before treatment, after the first cycle of chemotherapy, and after the second cycle of chemotherapy on the blood test (WBC, neutrophil and platelet, hemoglobin) changes, evaluation of appetite, nausea and vomiting, immune system (IgG,IgA,IgM, complement C3,complement C4) and KPS score of the quality of life. Observation data were analyzed by SPSS 17.0 statistical processing.Results:1. Myelosuppression-White blood cell:After the 1st cycle of chemotherapy, there was no significant difference between the control group and all treatment groups in white blood cell count. After the 2nd cycle of chemotherapy, white blood cell count on mild-warm moxibustion treatment group was statistical significantly increased when compared with control group (P< 0.05). Similarly, in wheat-grain cone moxibustion treatment group, the results showed that white blood cell count significantly obviously higher when compare with control group (P< 0.01). In addition to, there was statistical significantly increased on white blood cell count in wheat-grain cone moxibustion treatment group when compared with medicated moxa stick treatment group (P<0.05), but there were no statistical significant differences between the other groups.In the control group, the white blood cell count was slightly downward trend at after 1st cycle and after 2nd cycle of chemotherapy. However there was no significant difference (P>0.05). In medicated moxa stick treatment group, the white blood cell count was slightly downward trend at after 1st cycle and after 2nd cycle of chemotherapy when compare with before treatment. However there was no significant difference and the white blood cell count decreased lesser than control group (P>0.05).In mild-warm moxibustion treatment group, the white blood cell count was slightly downward trend at after 1st cycle of chemotherapy when compare with before treatment. Then after 2nd cycle of chemotherapy, the white blood cell count was slightly higher than 1st cycle but still lower than before treatment. However there was no significant difference and decreased lesser than control group (P>0.05). In wheat-grain cone moxibustion treatment group, the white blood cell count was slightly lower at after 1st cycle of chemotherapy when compare with before treatment. Then after 2nd cycle of chemotherapy, the white blood cell count was higher than before treatment. However there was no significant difference (P>0.05).-Neutrophil:After the first cycle of chemotherapy there was no statistical significant difference between the control group and all treatment groups. After the second cycle of chemotherapy, neutrophil cell count on wheat-grain cone moxibustion treatment group was significantly increased when compare with control group (P< 0.05). Although there were slightly increased of neutrophil cell count on medicated moxa stick treatment group and mild-warm moxibustion treatment group when compare with control group, but there were no statistical significant differences.In the control group, the neutrophil count was slightly downward trend at after 1st cycle and after 2nd cycle of chemotherapy, respectively. However it did not reach statistical significance (P>0.05). In medicated moxa stick treatment group, the neutrophil count was count was slightly downward trend at after 1st cycle of chemotherapy when compare with before treatment. Then after 2nd cycle of chemotherapy, the neutrophil count was slightly higher than 1st st cycle but still lower than before treatment. However there was no significant difference and decreased lesser than control group (P>0.05). In mild warm moxibustion treatment group, the neutrophil count was slightly downward at after 1st cycle and after 2nd cycle of chemotherapy when compare with before treatment. However there was no significant difference and the neutrophil count decreased lesser than control group (P>0.05). In wheat-grain cone moxibustion treatment group, the neutrophil count was slightly higher at after 1st cycle and after 2nd cycle of chemotherapy when compare with before treatment. However there was no significant difference (P>0.05).-Hemoglobin:After the 1st cycle of chemotherapy, there was no significant difference between the control group and all treatment groups on the count of Hemoglobin but in medicated moxa stick treatment group, there was slightly increased of Hemoglobin count when compare with control group (P> 0.05). After the 2nd cycle of chemotherapy, there was no statistical significance in the all treatment group (P> 0.05), compared with the control group on the count of Hemoglobin as well.In the control group, the Hemoglobin count was slightly downward at after 1st cycle and after 2nd cycle of chemotherapy. However it did not reach statistical significance (P>0.05). In medicated moxa stick treatment group, the Hemoglobin count was slightly higher at after 1st cycle of chemotherapy when compare with before treatment. Then after 2nd cycle of chemotherapy, the Hemoglobin count was drop lower than at after 1st cycle of chemotherapy and before treatment. However there were no significant differences and decreased lesser than control group (P>0.05). In mild warm moxibustion treatment group, the Hemoglobin count was no any statistical significance difference at after 1st cycle and after 2nd cycle of chemotherapy when compare with before treatment (P>0.05).In wheat-grain cone moxibustion treatment group, the Hemoglobin count was no any statistical significance difference at after 1st cycle and after 2nd cycle of chemotherapy when compare with before treatment (P>0.05).-Platelet:After the 1st cycle of chemotherapy, there were slightly increased of platelet count on medicated moxa stick treatment group, mild-warm moxibustion treatment group and wheat-grain cone moxibustion treatment group when compare with control group, but there was no statistical significant difference (P>0.05). After the 2nd cycle of chemotherapy, there were slightly increased of platelet count on medicated moxa stick treatment group, mild-warm moxibustion treatment group and wheat-grain cone moxibustion treatment group when compare with control group, but there was no statistical significant difference as well (P>0.05).In the control group, there was slightly decrease number of platelet when compare with before treatment at after 1st cycle and after 2nd cycle of chemotherapy, respectively. However it did not reach statistical significance (P>0.05).In medicated moxa stick treatment group, the platelet count was slightly downward trend at after 1st cycle and after 2nd cycle of chemotherapy when compare with before treatment. However there was no significant difference and the number of platelet count still higher than control group (P>0.05).In mild warm moxibustion treatment group, the platelet count was slightly downward trend at after 1st cycle and after 2nd cycle of chemotherapy when compare with before treatment. However there was no significant difference (P>0.05).In wheat-grain cone moxibustion treatment group, the platelet count was slightly downward trend at after 1st cycle and after 2nd cycle of chemotherapy when compare with before treatment. However there was no significant difference and the number of platelet count still higher than control group2. Gastrointestinal systems-Appetite:After chemotherapy treatment, the incidence rate of appetite on medicated moxa stick treatment group was statistical significantly decreased when compared with control group (P<0.05). Similarly, in wheat-grain cone moxibustion treatment group, the results showed that the incidence rate of appetite significantly obviously decreased when compare with control group (P<0.01). However there was no statistical significant difference between mild-warm moxibustion treatment group and control. Furthermore, the result showed that in the wheat-grain cone moxibustion treatment group, there were statistical significantly lower than medicated moxa stick treatment group (P<0.05), and obviously decreased when compare with mild-warm moxibustion treatment group on the incidence of appetite (P<0.01), but there were no statistical significant differences between mild-warm moxibustion treatment group and medicated moxa stick treatment group.-Nausea and vomiting:The incidence rate of nausea and vomiting on medicated moxa stick treatment group was statistical significantly obviously decreased when compared with control group (P<0.01). Similarly, in wheat-grain cone moxibustion treatment group, the results showed that the incidence rate of nausea and vomiting significantly obviously decreased when compare with control group (P<0.01). However there was no statistical significant difference between mild-warm moxibustion treatment group and control group. Furthermore, the result showed that in the medicated moxa stick treatment group and wheat-grain cone moxibustion treatment group, there were obviously significantly decreased on the incidence of nausea and vomiting when compared with mild-warm moxibustion treatment group (P<0.01)and (P<0.01),respectively on the incidence of nausea and vomiting, but there were no statistical significant differences between the medicated moxa stick treatment group and wheat-grain cone moxibustion treatment group.3. Functional statusAt after chemotherapy treatment, the results showed that the KPS score on all mild-warm moxibustion treatment group, medicated moxa stick treatment group and, wheat-grain cone moxibustion treatment group were obvious statistical significantly higher than control group at after chemotherapy treatment (P< 0.01). However there was no statistical significant difference among all treatment groups.4. Immune function-IgG:after the first cycle of chemotherapy, the result showed that there was obvious statistical significantly increased in medicated moxa stick treatment group when compared with control group on IgG (P< 0.01). There was also statistical significantly increased in medicated moxa stick treatment group when compared with mild-warm moxibustion treatment group (P< 0.05). Although, in mild-warm moxibustion treatment group there was slightly increased when compared with control group, but not significant (P> 0.05). After the second cycle of chemotherapy, IgG level on mild-warm moxibustion treatment group was statistical significantly increased when compared with control group (P< 0.05). Similarly, in medicated moxa stick treatment group, the results showed that there was significantly obviously higher when compare with control group (P< 0.01). After the third cycle of chemotherapy, IgG level on both of medicated moxa stick moxibustion treatment group and mild-warm moxibustion treatment group were obvious statistical significantly increased when compared with control group (P< 0.01).In the control group, the IgG was gradually downward lower with no significant at after 1st cycle, after 2nd cycle and, at after 3rd cycle of chemotherapy when compare with before treatment (P>0.05).In medicated moxa stick treatment group, at after 1st cycle of chemotherapy, IgG count was slightly higher than before treatment. Then after 2nd cycle and 3rd cycle of chemotherapy, IgG count started a bit lower than 1st cycle but still higher than before treatment. However there was no significant difference and decreased lesser than control group (P>0.05). In mild warm moxibustion treatment group, IgG was gradually higher at after 1st cycle, after 2nd cycle and, at after 3rd cycle of chemotherapy when compare with before treatment. Not only at after 2nd cycle of chemotherapy IgG was significantly higher than before treatment (P<0.05), but also at after 3rd cycle of chemotherapy IgG was significantly much higher than before treatment (P<0.01).-IgA; after the first cycle and the second cycle of chemotherapy, the result showed mat there were no statistical significantly differences between all groups (p>0.05). After the third cycle of chemotherapy, IgA level on mild-warm moxibustion treatment group were statistical significantly increased when compared with control group (P< 0.05).In the control group, the IgA was gradually downward trend at after 1st cycle, after 2nd cycle and after 3rd cycle of chemotherapy. However there was no significant difference (p>0.05). In medicated moxa stick treatment group, at after 1st cycle and 2nd cycle of chemotherapy, IgA count was slightly higher than before treatment. Then at after 3rd cycle of chemotherapy, IgA count started a bit decrease to same level as before treatment. However there were no significant differences (P>0.05).In mild warm moxibustion treatment group, IgA was gradually higher at after 1st cycle, after 2nd cycle and, at after 3rd cycle of chemotherapy when compare with before treatment. However there were no significant differences (P>0.05).-IgM:after the first cycle and the second cycle of chemotherapy, the result showed that there were no statistical significantly differences among all groups (p>0.05).After the third cycle of chemotherapy, IgM level on mild-warm moxibustion treatment group were statistical significantly increased when compared with control group (P< 0.05).In the control group and medicated moxa stick treatment group, the IgM was gradually downward trend at after 1st cycle, after 2nd cycle, and after 3rd cycle of chemotherapy. However there was no significant difference (p>0.05).But in mild warm moxibustion treatment group, IgM was gradually higher at after 1st cycle, after 2nd cycle and, at after 3rd cycle of chemotherapy when compare with before treatment. However there were no significant differences (P>0.05).-Complement C3:after the first cycle, the result showed that even though there was no statistical significantly difference among all groups on complement C3, but there was a slightly upward trend on medicated moxa stick treatment group and mild-warm moxibustion treatment group (p>0.05). After the second cycle of chemotherapy, complement C3 level on medicated moxa stick moxibustion treatment group was obvious statistical significantly increased when compared with control group (P< 0.01). In mild-warm moxbustion treatment group, there was slightly increased on level of complement C3 but not significant when compare with control group (p>0.05). On the other hand, after the third cycle of chemotherapy, complement C3 level on mild-warm moxibustion treatment group was obvious statistical significantly increased when compared with control group (P< 0.01). In medicated moxa stick treatment group, there was slightly increased on level of complement C3 but not significant when compare with control group (p>0.05).In the control group, the level of complement C3 was gradually downward trend at after 1st cycle, after 2nd cycle, and after 3rd cycle of chemotherapy. However there was no significant difference (p>0.05). In medicated moxa stick treatment group, at after 1st cycle of chemotherapy, there was no difference on C3 when compare to before treatment. At after 2nd cycle of chemotherapy, C3 were slightly increased then at 3rd cycle of C3 dropped to lower than before treatment but still higher than control group. However there were no significant differences (P>0.05). In mild warm moxibustion treatment group, C3 was gradually higher at after 1st cycle, after 2nd cycle and, at after 3rd cycle of chemotherapy when compare with before treatment. However there were no significant differences (P>0.05).-Complement C4:after the first cycle, even though there was no statistical significantly difference among all groups on complement C4, but there was a slightly upward trend on medicated moxa stick treatment group and mild-warm moxibustion treatment group (p>0.05). After the second cycle of chemotherapy, complement C4 level on mild-warm moxibustion treatment group was obvious statistical significantly increased when compared with control group (P< 0.01). In medicated moxa stick treatment group, there was slightly increased on level of complement C4 but not significant when compare with control group (p>0.05). After the third cycle of chemotherapy, complement C4 level on mild-warm moxibustion treatment group was obvious statistical significantly increased when compared with control group (P< 0.01). In medicated moxa stick treatment group, there was slightly increased on level of complement C4 but not significant when compare with control group (p>0.05). Furthermore, there was also statistical significantly increased in mild-warm moxibustion treatment group when compared with medicated moxa stick treatment group (P< 0.05).In the control group, the level of complement C4 was gradually lower at after 1st cycle, after 2nd cycle, and after 3rd cycle of chemotherapy. The results showed that at after 3rd cycle of chemotherapy, there was significantly lower than before treatment (P<0.05). In medicated moxa stick treatment group, at after 1st cycle and 2nd cycle of chemotherapy, there were no difference on C4 when compare to before treatment. But at after 3rd cycle of chemotherapy, C4 were slightly lower than before treatment but still higher than control group. However there were no significant differences (P>0.05). In mild warm moxibustion treatment group, C4 was gradually higher at after 1st cycle, after 2nd cycle and, at after 3rd cycle of chemotherapy when compare with before treatment. Not only at after 2nd cycle of chemotherapy that C4 was significantly higher than before treatment (P<0.05), but also at after 3rd cycle of chemotherapy C4 was significantly much higher than before treatment (P<0.01). Furthermore, at after 3rd cycle of chemotherapy we found that C4 was significantly higher than 1st cycle of chemotherapy (P<0.05).Conclusion:1. Moxibustion can reduce chemotherapy-induced myelosuppression, e.g. increase of WBCs, neutrophil count and slow down the rapidity of blood toxicity decreased levels damaged by chemotherapy drugs, wheat-grain cone moxibustion may have stronger efficacy curative.2. Moxibustion can significantly improve the toxicity of chemotherapy on the digestive tract. Medicated moxa stick and wheat-grain cone moxibustion may have stronger efficacy curative.3. Mild-warm moxibustion, medicated moxa stick, wheat-grain cone moxibustion can reduce the toxicity of chemotherapy, improve the systemic functional status of patients and improve the quality of life.4. Moxibustion can reduce the side effects of chemotherapy on the immunosuppression, mild-warm moxibustion may have stronger efficacy curative.5. Wheat-grain cone moxibustion is preferred method for treatment of the side effects of chemotherapy (less material consumption, less pollution, better effect). |
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