Clinical Observation Of Therapeutic Effect On Chemotherapy-induced Vomiting And Hepatorenal Function With Grain-moxibustion In Gynecologic Malignancy Patients

Objective:In order to provide a scientific basis for grain-moxibustion, we explored the therapeutic effect of chemotherapy-induced vomiting, liver and kidney dysfunction and holistic health with grain-moxibustion in gynecologic malignancy patients.Methods:Fifty gynecology malignancy patients were randomly divided into two groups on a fifty-fifty basis. One is treatment group and the other is control group. Both of the two groups received conventional chemotherapy and anti-venom medicine. However, treatment group received an additional grain-moxibustion treat. The main moxibustion points were Zusanli (ST36) and Dazhui (GV14). One period of course is a treatment of successful7days and once a day. A continuous two courses were performed for the patients. The patients’vomiting symptom was recorded and scored by using a criterion suggested by Europe Society of Clinical Oncology. A comparative evaluation of pretherapy and post-treatment for the patients’liver indexes (total bilirubin, alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase), kidney indexes (blood urea nitrogen, creatinine), and overall condition (body weight, physical condition and quality of life) was investigated. The results were statistical analyzed by SPSS19.0software.Results:Score comparison of chemotherapy-induced vomiting symptom between two groups in the post-treatment:During the first period, the treatment group’s vomiting scores in the third day was lower than the first day(P>0.05), and the seventh day’s was lower than the first day’s(P<0.01). The control group’s vomiting scores in the third day was also lower than the first day (P>0.05), so was the seventh day. There was no statistically significantly difference found between two groups at the same time(P>0.05).During the second period, the treatment group’s scores had a downside. The difference between the first day and the third day on vomiting scores was statistically significant(P<0.05). The significantly difference was also found between the first day and seventh days of treatment group (P<0.01). Besides, there was no significantly difference between the control group’s score in the third day and the first day(P>0.05). There was no significantly difference between the control group’s score in the seventh day and the first day, too. The vomiting score had significant difference between the two groups in the seventh day of second period (P<0.01).Comparison of hepatorenal function between the two groups in pretherapy and post-treatment:The hepatorenal function showed no significant change in both groups before and after treatment(P>0.05), and it was also not significantly different between the two groups.Comparison of overall healthy between the two groups in pretherapy and post-treatment:The weight showed no significant change in both groups before and after treatment(P>0.05), and it was also not significantly different between the two groups.The control group’s KPS score in the post-treatment was lower than the pretreatment (P<0.01), while the changes of the treatment group were not obvious(P>0.05). After treatment, the treatment group’s score was higher than the control group(P<0.05).The control group’s QLQ scores in the post-treatment was lower than the pretreatment(P<0.05), while the changes of the treatment group were not obvious(P>0.05). After treatment, The difference between the two groups was statistically significant (P<0.01).Conclusion:Grain-moxibustion could treat chemotherapy-induced vomiting. Otherwise, grain-moxibustion can retard the deterioration rate of performance status, and improve the quality of life.