| Background: Coronary atherosclerotic heart disease(CHD),referred to as coronary heart disease,refers to the coronary artery on the heart that causes stenosis,spasm,or occlusion of the arterial lumen that supplies blood to the heart due to a series of factors.Ischemia and hypoxia,severe myocardial necrosis occurs in patients with clinical manifestations of chest pain,chest tightness,belching,even accompanied by double upper limb ulnar,back or shoulder neck radiation pain.In cardiovascular diseases,coronary heart disease is a common and frequently-occurring disease.Its mortality rate is extremely high.It ranks first in the deaths of adult cardiovascular disease in China,seriously reducing people's quality of life and damaging people's health.Severe consumption of medical and social resources has brought suffering to every family,increased the economic burden on each family,and also consumed social and medical resources,placing a heavy burden on the country.With the advancement of medical care at the current stage,the aging of society is accelerating,China is in a period of rapid socialist economic development,material resources are greatly enriched,and people's living standards are increasing.This has led to the development of coronary heart disease in recent years.As a result of their younger age,their morbidity and mortality rates are still rising.The cause of coronary heart disease is extremely complex.After years of research,it is currently agreed that it is related to age,genetics,environment,living eating habits,obesity,inflammation,metabolism,etc.The main pathological changes are coronary artery wall sclerosis,porridge Plaque formation,or coronary vasospasm,etc.,on the basis of plaque rupture,thrombosis.In recent years,with the development of medicine,the research on cardiovascular diseases has been deepened,and a variety of markers related to atherosclerosis have been identified,among which interleukin,tumor necrosis factor,and high-sensitivity C-reactive protein(Hs-CRP)The correlation between serum complement(C1q)and coronary heart disease has received extensive attention from domestic and foreign experts,scholars and clinicians.There are also a large number of articlesreporting some research results.However,most of the studies reported are based on the relationship between a single index and coronary heart disease,and there are contradictions in the results reported by different researchers.Therefore,the purpose of this study is to examine the levels of serum complement C1 q and Hs-CRP in combination.The correlation between the two and coronary heart disease provides the basis for clinical diagnosis and evaluation of the disease.Objective: To explore the correlation between serum C1 q,hypersensitive C-reactive protein(hs-CRP)and coronary atherosclerotic heart disease(CHD).Methods: The clinical data of 488 patients hospitalized in the Department of Cardiology of Dongfeng General Hospital of Hubei Medical University between October 2016 and April 2017 were retrospectively analyzed.According to the inclusion criteria and exclusion criteria,406 patients were finally selected.All patients passed the coronary examination.Artery angiography,according to the history of previous coronary intervention or coronary angiography,whether the degree of coronary stenosis was ? 50%,406 patients were divided into control group(200 cases)and coronary heart disease group(206 example).The serum complement C1 q and Hs-CRP levels were compared between the two groups.Logistic regression was used to analyze the risk factors of coronary heart disease.206 patients with coronary heart disease(according to the American Society of Cardiology(ACC)/ American Heart Association(AHA),the European Society of Cardiology(ESC)and the Chinese Medical Association developed the criteria for the name and diagnosis of coronary heart disease)were further divided into stable angina group(68 patients),unstable angina pectoris(86 patients),acute myocardial infarction(52 patients)(including acute ST-elevation myocardial infarction,non-ST elevation myocardial infarction),serum complement was compared between the three groups C1 q,Hs-CRP levels.Statistical methods: SPSS 22.0 statistical software was used to analyze and process the data.Normally distributed measurement data were expressed as mean±standard deviation(x±s).The t-test was used for the comparison between groups.The count data was expressed as a percentage,and the ?2 test was usedas the comparison between groups.Multivariate Logist regression analysis was used to comprehensively assess independent risk factors for coronary heart disease,and odds ratios(OR values)and 95% confidence intervals(95% CI)were calculated.The difference was statistically significant at P < 0.05.Results: The level of serum C1 q in the control group was(195.32 ± 65.50)mg / L and the level of C1 q in coronary heart disease group was(175.75 ±40.76)],the difference was statistically significant(P <0.05))Mg / L,the level of HsCRP in coronary heart disease group was(3.86 ± 1.22)mg / L,the difference was statistically significant.Logistic multivariate regression analysis showed that in the coronary heart disease group the age(OR = 1.036,95%CI =1.009~1.064,P < 0.05),diabetes(OR = 4.629,95%CI = 2.159~9.924,P < 0.05),LDL(OR = 2.965,95%CI = 1.286~6.835,P < 0.05),GLU(OR = 1.033,95%CI =1.246~1.856,P < 0.05),Hs-CRP(OR = 1.509,95%CI = 1.225~1.859,P <0.05)were the risk factors for CHD and the C1q(OR = 0.991,95%CI = 0.983~0.998,P < 0.05)was the protective factor.The serum C1 q level in the control group was(195.32±65.50)mg/L,and the serum C1 q level in the coronary heart disease group was(175.75±40.76)],the difference was statistically significant(P<0.05);the serum Hs-CRP level in the control group was(2.74)The serum Hs-CRP level in coronary heart disease group was(1.86±1.22)mg/L,with a statistically significant difference.Logistic multivariate regression analysis showed that age(OR = 1.036,95% OR = 1.009 to 1.064,P <0.05),diabetes(OR= 4.629,95% OR = 2.159 to 9.924,P <0.05),LDL(OR = 2.965,95% CI = 1.286 to 6.835,P < 0.05),GLU(OR = 1.033,95% OR = 1.246 to 1.856,P <0.05),Hs-CRP(OR = 1.509,95% OR = 1.225 to 1.859,P <0.05)is a risk factor for CHD.C1q(OR = 0.991,95% OR = 0.983 to 0.998,P < 0.05)is a protective factor for coronary heart disease.The subgroup analysis of coronary heart disease group showed that the serum Hs-CRP level was(2.86±1.24)mg/L in the stable angina group,and the serum Hs-CRP level was(8.67±1.62)mg/L in the unstable angina group.The serum Hs-CRP level in the infarction group was(12.56±2.23)mg/L.The difference between the acute myocardial infarction group and theunstable angina group was statistically significant(P < 0.05).The comparison between the unstable angina group and the stable angina group was statistically significant.There was a statistically significant difference(P < 0.05).There was a statistically significant difference between the acute myocardial infarction group and the unstable angina pectoris group compared with the stable angina pectoris group(P < 0.05).The serum C1 q level was(184.22±48.32)mg/L)in the stable angina pectoris group.48.32)mg/L,serum C1 q level in the unstable angina group was(146.72±36.14)mg/L,serum C1 q level in the acute myocardial infarction group was(152.44±33.60)mg/L,acute myocardial infarction group and unstable angina There was no significant difference between the two groups(P> 0.05);the difference between the acute myocardial infarction group and the stable angina group was statistically significant(P < 0.05);the unstable angina group and stable angina were compared.Statistically significant different(P<0.05);Conclusion: Serum C1 q is negatively correlated with coronary heart disease,and Hs-CRP is positively correlated with coronary heart disease.Both of them are reliable markers of coronary heart disease.The combined detection of serum C1 q can be used as a reliable clinical diagnosis and assessment index of coronary heart disease.. |
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