Study On Relationship Between Age, Low Density Lipoprotein Cholesterol, C-reactive Protein,the Severity Of Coronary Arteryand Serum Interleukin-6 In Patients With Coronary Atherosclerotic Heart Disease

Objective: To investigate the Correlation study of serum interleukin-6and age, low density lipoprotein cholesterol, c-reactive protein in patients with coronary atherosclerotic heart disease and the influence on the severity of coronary atherosclerotic heart disease.Methods: 1) 349 patients admitted to the hospitalbecause of chest pain were retrospectively analyzed, including 90 cases of the patients with normal coronary angiography examination as control group, the other259 cases after coronary angiography for coronary heart disease as a group of coronary artery disease. coronary atherosclerotic heart disease group was further divided into 2 subgroups, group respectively for stable angina(SAP)(173 cases), acute coronary syndrome(ACS)(86 cases). The Gensini score was used to judge the severity of coronary atherosclerotic heart disease; 2) For all of the349 patients were enrolled and used to detect all index in the first 24 hour in the hospital;using Logistic regression analysis of the indicators in relation to coronary atherosclerotic heart disease, and to analyze the correlation between serum IL-6 and each index. Further multivariate stepwise regression analysis was used to find the factors independently associated with serum IL-6; 3) Analysis of One-way analysis of variancewas used to compare the serum level of IL-6in coronary atherosclerotic heart disease subgroups.Result: 1) SerumIL-6, age, low density lipoprotein cholesterol, c-reactive protein,Hypertension, CHD family historyin patients with coronary atherosclerotic heart disease(P < 0.05) arehiger than controls; high density lipoprotein cholesterol are lower than controls(P < 0.05); 2) Serum IL-6 is positiverelated to sex(r=0.135, P=0.030), age(r=0.175, P < 0.01), Hypertension(r=0.102, P=0.024), CHD family history(r=0.110,P=0.015), low density lipoprotein cholesterol(r=0.194, P < 0.01), c-reactive protein(r=0.655, P<0.01); Serum IL-6 is negative related to HDL(r=-0.239, P<0.01) and no related to TG、TC、SBP、DBP、HCY; 3) The level of serum IL-6 in either ACS group or SAP group is higher than controls, ACS group is higher than SAP group, SerumIL-6is significantlyrelated toseverityof coronary heart disease(Gensini score)(r=0.526, P <0.001) and the level of IL-6 increased with the increase of Gensini score.. Conclusion: 1)The serum IL-6 is significantly associated with coronary atherosclerotic heart disease and is one of the hazards of coronary heart disease; 2) Serum IL-6 is related with sex, age,Hypertension, CHD family history, low density lipoprotein cholesterol, c-reactive protein;3) In coronary atherosclerotic heart disease subgroup, the serum level of IL-6 is higher than those in control group; the higher serum IL-6 level is, the severer with coronary atherosclerotic heart disease lesion degree.