| Objective To explore the changes and clinical significance of serum soluble glycoprotein-130 (sgp130) and hypersensitive C-reactive protein (hs-CRP) levels in patients in coronary heart disease (CHD).Methods By using enzyme-linked immunosorbent assay (ELISA) and light scattering rate nephelometry method, sgp130 and hs-CRP were measured in 20 acute myocardial infarction (AMI),20 unstable angina pectoris (UAP),20 stable angina pectoris (SAP) and 20 controls.Results The serum sgp130 and hs-CRP in the CHD patients were lower and higher than those in the controls (t=6.97,6.86, P<0.01). The serum level of sgp130 in patients with AMI was much lower than that of UAP,SAP and the controls (F=47.14,q=4.59-15.66, P<0.01). The sgp130 level were much lower in patients with UAP than that of SAP and the controls (F=47.14,q=4.26-11.06, P<0.01), the level of sgp130 in patients between SAP and the controls was different(F=47.14, q=4.93, P<0.01); The serum level of hs-CRP in patients with AMI was much higher than that of UAP,SAP and the controls (F =36.23,q=7.52-13.51, P<0.01). The hs-CRP level were much higher in patients with UAP than that of SAP and the controls (F=36.23,q=4.26-5.99, P<0.01), the level of hs-CRP in patients between SAP and the controls was different (F=36.23,q=4.26, P> 0.05); The level of sgp130 in patients with CHD was negatively correlated with hs-CRP (r =-0.574, P<0.01). The area under the ROC curve (AUCROC) were all greater than 0.9 with higher sensitivity and specificity. The sensitivity and specificity of sgp130 and hs-CRP is 0.95/0.90 and 0.91/0.95 in patients with AMI. The sensitivity and specificity of sgp130 and hs-CRP is 0.94/0.90 and 0.90/0.95 in patients with UAP. Conclusions The changes of sgp130 and hs-CRP had higher accuracy on the diagnosis of AMI,UAP. The changes may be helpful in indicating of enhancement of inflammation and the severity of coronary heart disease. |
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