| Purpose:The primary objective of this project was to investigate the therapeutic effect of acupuncture in the treatment of patients with polycystic ovary syndrome with spleen deficiency and phlegm-dampness evidence by combining acupuncture with the treatment protocol of selfdeveloped formula for strengthening the spleen and resolving phlegm plus drospirenone ethinyl estradiol tablets,in order to provide clinical data for the treatment of polycystic ovary syndrome with acupuncture.Material and method : Sixty-eight patients with polycystic ovary syndrome who satisfied the inclusion requirements were collected from the gynecology clinic of Liaoning Provincial Hospital of Traditional Chinese Medicine and randomly divided into 34 cases each in the control group and the acupuncture group.The control group was provided with the selfprepared formula for spleen and phlegm removal plus drospirenone ethinyl estradiol tablets,while the acupuncture group was treated with snap acupuncture combined with the selfprepared formula for spleen and phlegm removal plus drospirenone ethinyl estradiol tablets for a total of three menstrual cycles.The changes of body mass index(BMI),glucolipid metabolic indexes such as fasting blood glucose(FPG),triglycerides(TG),total cholesterol(TC),highdensity lipoprotein(HDL),low-density lipoprotein(LDL),sex hormone indexes such as luteinizing hormone(LH),follicle stimulating hormone(FSH),testosterone(T),and TCM syndrome score were observed before and after treatment in both groups.The data were statistically analyzed.Four cases were shed due to personal and social factors of patients.Finally 64 cases completed clinical observation,33 cases in the needle and medicine group and31 cases in the control group.Results:1.Clinical efficacy analysis: After 3 months of treatment,the CM evidence points of patients in both groups decreased,and compared with the control group,the decrease in the acupuncture and medicine group was obvious and statistically significant(P<0.0001);the comprehensive efficacy of treatment was evaluated according to the physical and chemical indexes and follow-up data of patients,and the difference in the total effective rate between the two groups was statistically significant(P=0.003).2.Body mass index(BMI): BMI reduced in both groups after treatment;compared with the control group,it decreased significantly in the needle and medicine group,which was statistically significant(P=0.002).3.Blood glucose and lipid indexes: by t-test,the FPG and TG of patients in both groups showed statistically significant decreases after treatment compared with those before therapy;the FPG of the needle medicine group decreased significantly compared with the control group,and the difference was statistically significant(P=0.046);the TC and LDL of patients in both groups decreased after therapy,and the decrease in the control group was not statistically significant(P=0.326,P=0.214);the TC and LDL of the needle medicine group decreased significantly,and the difference was statistically significant(P=0.002).TC and LDL decreased significantly,which was statistically significant(P=0.015,P=0.006);HDL increased in both groups after treatment,which was statistically significant(P<0.05),but the difference between the two groups after treatment was not statistically significant(P=0.393).4.Sex hormone level: by t-test,LH and T decreased in both groups after treatment,and declined significantly in the needle medicine group compared with the control group,all of which were statistically significant(P < 0.05);FSH decreased in both groups after treatment,which was statistically significant(P < 0.05),and the difference in FSH change between the two groups after treatment was not statistically significant(P = 0.797).By rank sum test,the LH/FSH ratio decreased significantly in both groups after treatment,and the decrease in LH/FSH value in the needle medicine group after treatment was more significant than that in the control group,and the discrepancy was statistically significant(P < 0.05).5.Follow-up comparison: The number of normal monthly cycles in the injection-medicine group(28)was more than that in the control group(7)at follow-up(P<0.0001),with a statistical significant difference.Conclusion:The effectiveness of acupuncture combined with the self-prepared formula for strengthening the spleen and resolving phlegm plus drospirenone ethinyl estriol in treating PCOS with spleen deficiency and phlegm dampness was superior to that of only the formula for strengthening the spleen and resolving phlegm plus drospirenone etestrol tablets,and the efficacy in lowering blood glucose,blood lipids and improving sex hormone levels was also significantly better than that of the control group after treatment.The procedure is simple and safe,with less patient pain,and has a prospect of wide clinical application. |
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