Clinical Observation On The Treatment Of Obese Polycystic Ovary Syndrome By Invigorating The Spleen And Resolving Phlegm

Object:To observe the clinical efficacy of the method of strengthening the spleen and resolving phlegm in the treatment of obese polycystic ovary syndrome(PCOS),and to further explore its mechanism of treatment of obese polycystic ovary syndrome.Signs open up new ideas to guide clinical treatment.Methods:From March 2019 to March 2020,60 obese patients with polycystic ovary syndrome were selected from the gynecological clinic and ward of Nan Jing Hospital of traditional Chinese medicine.Sixty patients were divided into two groups by random number table method,which were the control group(metformin oral)and the treatment group(Jianpi Huatan Recipe combined with metformin oral).After one course of treatment(3 months),observe changes in menstrual cycle,quantitative scores of spleen deficiency,phlegm and dampness syndrome,efficacy of TCM syndromes,obesity-related indicators(BMI,WHR),and hormone levels(LH,FSH,LH/FSH,T,SHBG,AMH),glucose metabolism related(FPG,FINS,HOMA-IR),ovarian volume and BBT curve changes.The statistical efficacy of the two groups was evaluated by statistical software SPSS 25.0.Results:Before treatment:general items(age,duration),menstrual cycle,TCM syndrome score,BMI,WHR,hormone levels(LH,FSH,LH/FSH,T,SHBG,AMH),fasting blood glucose,FINS,HOMA between the two groups-IR,ovarian volume,and BBT curve changes showed that the difference was not statistically significant and comparable.The treatment group can effectively improve the menstrual cycle of the patients,while the control group does not improve the menstrual cycle of the patients,and there is a significant difference between them(P=0.026<0.05).In terms of improving TCM symptoms,the TCM symptom scores of the two groups were lower than before treatment,and there was a significant difference between the groups(P<0.05).Both groups could reduce the levels of BMI and WHR in obese PCOS patients.Compared with the two groups,the differences were significant(P=0.009,0.03<0.05),indicating that the treatment group had a better effect on reducing BMI and WHR than the control group.Both groups could improve the levels of LH,LH/FSH,SHBG,and AMH in patients.There was a statistically significant difference between the groups(P=0.005,0.004,0.032,0.002,0.001<0.05);the treatment group reduced LH,LH/FSH,AMH level and the effect of increasing SHBG were better than those of the control group;the two groups had similar efficacy in reducing FSH level without significant difference(P=0.507>0.05).Both groups could reduce the levels of FPG,FINS and HOMA-IR in patients.Comparing between the groups,P=0.033,0.039,0.026<0.05,which was statistically different.The difference between the two groups in reducing ovarian volume was statistically significant(P<0.05).The bidirectional rate of BBT in the treatment group was higher than that in the control group during treatment,P<0.05.The total effective rate in the treatment group was 93.3%,and the effective rate in the control group was 83.3%.The difference between the two groups was statistically significant(P=0.004<0.05).The treatment group was adjusting the menstrual cycle,improving TCM syndromes,weight loss,and regulation.The efficacy of endocrine and glucose metabolism was significantly better than the control group.No significant adverse reactions were found during the treatment in the two groups,and there were no abnormal changes in blood routine,liver and kidney function,and electrocardiogram.Conclusion:The method of strengthening spleen and resolving phlegm is effective in treating obese patients with PCOS,without obvious adverse reactions.It can adjust the menstrual cycle,alleviate the clinical symptoms of TCM,reduce weight,improve some hormone levels and glucose metabolism disorders,and ovaries in patients.The reduction in volume and the restoration of basal body temperature have obvious curative effects,providing new ideas for clinical dialectical treatment.