Clinical Study On Kashuangping Combined With Jianpi Huatan Prescription In The Treatment Of PCOS With Phlegm-dampness Syndrome And Insulin Resistanc

Purpose:By observing the clinical study on the treatment of PCOS with insulin resistance in phlegm-dampness evidence by combining Kashuangping with the formula of strengthening spleen and resolving phlegm,a theoretical discussion on the protocol was conducted to provide theoretical support and scientific basis for clinical application.Material and method:Sixty-eight patients with phlegm-dampness evidence of PCOS-IR who met the criteria were selected and randomly divided into 34 cases of the control group and 34 cases of the treatment group.The control group was treated with Ursine plus Kashuangping,while the observation group was treated with the self-prepared formula for strengthening the spleen and resolving phlegm for 3 menstrual cycles on top of the control group.The Chinese medicine syndrome score,body mass index,waist-hip ratio,sex hormone value,blood lipids,blood sugar and insulin level were compared and analysed before and after treatment in both groups,followed by a 3-month menstrual follow-up observation.Results:1.Comprehensive efficacy: the effective rate of the observation group(90%)was higher than that of the control group(66%),which was statistically significant(p<0.05).2.Chinese medicine evidence points: the scores of patients in both groups decreased after treatment,with statistically significant comparison within and between groups(p<0.01).3.BMI and WHR: The BMI values of patients in both groups decreased significantly after treatment(p<0.01),and WHR did not improve significantly before and after treatment(p>0.05).4.Sex hormone values: LH,LH/FSH and T values improved in both groups after treatment(p<0.05),and the improvement was more obvious in the observation group;FSH values did not improve significantly before and after treatment(p>0.05).5.Insulin resistance: HOMA-IR decreased significantly in both groups after treatment(p<0.01),and the decrease in the observation group was better than that in the control group(p<0.01).6.Glucose and lipid metabolic indexes: HDL-C,TG,TC,FINS and FPG values in both groups improved after treatment(p<0.05),and the improvement was more obvious in the observation group;LDL-C values in both groups had comparable efficacy and there was no statistical difference(p>0.05).7.Chinese medicine evidence points in the follow-up period: the observation group had statistically significant(p<0.01)compared with the control group in the follow-up.Conclusion:1.In this study,both the control group(Ursimine combined with Kashuangping)and the observation group(Ursimine and Kashuangping plus Jianshuangping formula)achieved certain efficacy in the treatment.The combined efficacy of the addition of the Chinese medicine Jianshuangping formula in treating PCOS-IR was better than that of Ursimine and Kashuangping alone,and this protocol can be applied clinically to treat the relevant pathological conditions.2.The combination of the formula for strengthening the spleen and resolving phlegm with the western medicines Ursimine and Kashuangping can effectively improve the TCM clinical symptoms of PCOS-IR and promote the restoration of normal menstruation.3.This regimen can effectively regulate the levels of sex hormones and glucolipid metabolism,and can shorten the course of the disease with a high degree of safety.