| The first study:Meta-analysis of the curative effect of Fuzheng Jiedu method on coagulation dysfunction in sepsisObjective:Using Meta-analysis to explore whether Fuzheng Jiedu method had a regulatory effect on coagulation function in patients with sepsis.Methods:By retrieving the clinical RCT studies on the use of Fuzheng Jiedu Chinese medicine in the treatment of sepsis with coagulation disorders in patients.Using Review Manager 5.4 to analyze the extracted experimental data,and finally arrive at a conclusion.Results:A total of 13 literatures that met the criteria were included.A total of six coagulation-related indicators including TT,PT,APTT,PLT,Fib,and D-D were collected.SOFA score and APACHE-II score were used to evaluate the prognosis of patients.Conclusion:Fuzheng Jiedu Chinese medicine can improve the coagulation function of patients with sepsis and reduce the patient’s condition.The second study:Study on the effect of Fuzheng Touxie Decoction on coagulation dysfunction in patients with sepsisObjective:1 Explore the effect of Fuzheng Touxie Decoction on coagulation dysfunction in sepsis.2 Explore whether Fuzheng Touxie Decoction can improve vascular endothelial cell injury in patients with sepsis.3 Explore the effect of Fuzheng Touxie Decoction on the clinical prognosis of patients with sepsis.Methods:Use the clinical experimental method of prospective randomized controlled study.From 2022.3 to 2023.2,patients with sepsis from ICU and EICU of Dongcheng District and Tongzhou District of Dongzhimen Hospital were collected.The experimental group was treated with Fuzheng Touxie Decoction on the basis of basic western medicine treatment.Record the SDC-1、PLT、PT、APTT、TT、FIB、FDP、D-D、AT-Ⅲ、WBC、NE%、CRP、PCT of the two groups on the 0 th,3 rd and 7 th day.Record APACHE-Ⅱ score and TCM syndrome score on the 0 th and 7 th day.On day 28,record the 28-day mortality.Use SPSS26.0 statistical tool analyze.The data of the two groups of patients were compared with each other between groups and within groups,and the research conclusions were drawn.Results:1 Inclusion of cases:A total of 30 hospitalized patients with sepsis were included in this study and randomly divided into control group and experimental group.During the study period,2 patients fell off due to withdrawal from the test,2 patients fell off due to death,2 patients fell off due to the addition of anticoagulant drugs during treatment,and 1 patient fell off due to transfer.Finally,23 cases were collected,including 11 cases in the control group and 12 cases in the experimental group.2 Comparison results of main efficacy indexes:(1)SDC-1:①group comparison:The mean SDC-1 values of the two groups on the 7th day of treatment were 27.21 and 23.45,and the difference was statistically significant(P=0.048<0.05).②Comparison within the control group:The values of SDC-1 in the control group on day 0 and day 3 were 26.37 and 27.57,respectively,showing an upward trend,and the difference was statistically significant(P=0.02<0.05).③Comparison within the experimental group:The values of SDC-1 in the experimental group on days 0 and 7 were 26.5 and 23.45,respectively,and the difference was statistically significant(P=0.021<0.05).(2)coagulation index:①group comparison:On the third day of treatment,the mean values of APTT in the control group and the experimental group were 37.42 and 27.45,respectively,and the difference was statistically significant(P=0.004<0.01).On the 7th day of treatment,the PT values of the control group and the experimental group were 15.81 and 12.97,respectively,and the difference was statistically significant(P=0.002<0.01).The APPT values were 39.71 and 26.08,respectively,and the difference was statistically significant(P=0.001<0.01).②Comparison within the experimental group:The PT values of the control group on days 0,3 and 7 were 14.23,14.25 and 15.81,respectively.The PT value on day 7 was significantly different from that on days 0 and 3(P=0.029,0.047<0.01).(3)Comparison within the experimental group:The PLT values of the experimental group on days 0,3,and 7 were 211,241,and 280,respectively.The difference between the 7th day and the 0th day,the 3rd day and the 0th day was statistically significant(P=0.013,0.009,0.043<0.05).The PT values on days 0,3,and 7 were 14.75,12.02,and 12.97,respectively.The PT value on the 7th day was significantly different from that on the 0th and 3rd days(P=0.013,0.006<0.05).The APTT values on days 0,3,and 7 were 31.81,27.25,and 23.45,respectively.The APPT value on the 7th day was significantly different from that on the 0th and 3rd days(P=0.02,0.005<0.05).D-D was 1.72 and 0.9 on days 0 and 7,respectively.The difference was statistically significant(P=0.034<0.05).3 Comparative results of secondary efficacy indicators:(1)inflammatory index:①group comparison:On the third day,the PCT value of the experimental group was lower than that of the control group,and the difference was statistically significant(P=0.008<0.01).On the 7th day,the CRP value of the experimental group was lower than that of the control group,and the difference was statistically significant(P=0.003<0.01).②Comparison within the experimental group:NE%on the 7th day was lower than that on the 3rd day,and the difference was statistically significant(P=0.049<0.05).The CRP value on day 7 was lower than that on day 0 and day 3,and the difference was statistically significant(P=0.01,0.028<0.05).(2)SOFA score:①group comparison:On the 7th day,the SOFA score of the experimental group was lower than that of the control group,and the difference was statistically significant(P=0.046<0.05).②Comparison within the control group:The third day was lower than the first day,and the difference was statistically significant(P=0.007<0.01).③Comparison within the experimental group:The 7th day was lower than the 0th and 3rd day,and the difference was statistically significant(P=0.012,0.004,0.006<0.05).(3)APACHE-II score:①group comparison:After treatment,the experimental group was lower than the control group,the difference was statistically significant(P=0.038<0.05).②interclass:The score of the experimental group on the 7th day was lower than that on the 0th day,and the difference was statistically significant(P=0.001<0.01).(4):chinese medicine syndrome scores:After treatment,the scores of the two groups were lower than those before treatment,and the difference was statistically significant(P=0.036,0.002<0.05).Conclusion:1 Fuzheng Touxie Decoction may regulate coagulation function in patients with sepsis by protecting vascular endothelial cells;2 Fuzheng Touxie Decoction can reduce the inflammatory response in patients with sepsis;3 Fuzheng Touxie Decoction may improve the prognosis of patients by improving the coagulation function of patients with sepsis. |
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