Effect Of Qingrejiedu Fuzheng Decoction On Cardiopulmonary Function In Patients With Phlegm-heat Stasis Syndrome Of Pulmonary Sepsis

Objective: To investigate the effect of Qingrejiedu Fuzheng Decoction on cardiopulmonary function in patients with phlegm-heat stasis syndrome of pulmonary sepsis.At the same time,to look for a new therapeutic target and therapeutic drug for the integrated traditional Chinese and western medicine treatment of pulmonary sepsis by comparing with the therapeutic effect of Xuebijing injection,laying a foundation for the development of nosocomial preparations.Methods: According to the experimental methods and inclusion criteria and considering the dropout factors,72 patients with phlegm-heat and blood stasis syndrome of pulmonary sepsis were selected and randomly divided into treatment group(n = 36)and control group(n = 36).The treatment group was treated with Qingrejiedu Fuzheng Decoction(Oral administration 100 ml/time 3 times/day),and the control group was treated with Xuebijing Injection(Intravenous drip 50 ml once/day).The course of treatment was 11 days in total,and the treatment group and control group were both given basic western medicine treatment.The main symptoms and signs,secondary symptoms and signs,blood gas analysis results(PaCO2 and PaO2),oxygenation index(OI),hemodynamic cardiac output and cardiac index(CO and CI),changes in TCM score and related laboratory tests were observed before and after treatment in the treatment group and control group to evaluate the effectiveness and safety of the two treatment methods.Results:1.Comparison of general data: There were no significant differences in age andgender before treatment between the two groups(P > 0.05),which were comparable.2.The results of blood gas analysis(PaCO2 and PaO2),oxygenation index(OI),hemodynamics cardiac output and cardiac index(CO and CI)and TCM syndrome score before and after treatment in the two groups were statistically significant(P <0.01).It indicated that the therapeutic effect of both groups was both well.3.There was no significant difference in blood gas analysis(PaCO2 and PaO2),oxygenation index(OI),hemodynamics(CO and CI)and TCM score after treatment between the two groups(P > 0.05).It indicated that there was no significant difference in the therapeutic effect between the treatment group and the control group.4.TCM efficacy determination: In the treatment group,1 case was cured,17 cases were markedly effective,8 cases were effective,4 cases were ineffective,with an overall response rate of 86.66%.In the control group,1 case was cured,18 cases were markedly effective,8 cases were effective,and 3 cases were ineffective.There was no significant difference between the two groups(P > 0.05),indicating that there was no significant difference in the curative effect of TCM between the two groups.6.Safety analysis: During the treatment,the vital signs,liver and kidney function,urination and defecation routine,ECG showed no significant changes in the two groups.The patients in the two groups had no obvious adverse reactions and toxic and side effects during treatment.