| Objective:To observe the clinical efficacy and safety index of Danggui Dizhu Decoction combined with berberine hydrochloride oil in the treatment of hormone-dependent facial dermatitis of blood deficiency and wind dryness syndrome;to observe the characteristics and changes of dermoscopy in patients with hormone-dependent dermatitis in the face of blood deficiency and wind dryness syndrome.Methods: According to the complete randomization table,88 cases eligible for admission were divided into a treatment group(44 cases)and a control group(44 cases).Treatment group scheme: oral Chinese medicine Danggui Dizhu Decoction+external use of berberine hydrochloride oil,control group scheme: external use of berberine hydrochloride oil.At the same time,both groups were treated with oral desloratadine tablets+external boric acid solution during the progress period.Blood routine,liver function,renal function,and dermatoscopy were performed before and after treatment;Before treatment and 2,4,8,and 12 weeks after treatment,the two groups of patients were observed and recorded,including TCM syndromes,subjective symptoms,objective symptoms,skin disease quality of life index,and the conclusion was reached after statistical analysis with SPSS 26.0software.Results:A total of 88 cases were included in this clinical observation,8 cases were excluded and dropped off,and 80 cases were actual cases.The following results are obtained after statistical analysis:1.Comparison of TCM symptoms scoresThe difference in TCM syndrome scores between the two groups was statistically significant(P < 0.05),and the results suggested that the two groups could improve TCM syndromes: the treatment group improved TCM syndromes 2 weeks after treatment,and the control group improved TCM syndromes 8 weeks after treatment.The comparison of TCM syndrome scores between the two groups(P < 0.05)showed that the improvement of TCM syndrome in the treatment group was better than that in the control group after 2,4,8,and 12 weeks of treatment(P < 0.05).2.Comparison of self-conscious symptom scoresA comparison of scores and total scores of conscious symptoms between the two groups(P < 0.05)showed that both groups could improve conscious symptoms.After 2 weeks of treatment,the two groups had similar improvement in burning,itching,and tightness(P > 0.05).2 weeks after treatment,the improvement in pain was as follows: the treatment group was better than the control group(P < 0.05);At 4 weeks,8weeks,12 weeks after treatment,the improvement of burning,itching,tightness: the treatment group was better than the control group(P < 0.05).Comparing the total score of conscious symptoms between the two groups,the improvement of conscious symptoms in the two groups was as follows: 2 weeks after treatment,the two groups were similar(P > 0.05);At 4 weeks,8 weeks,and 12 weeks,the treatment group was better than the control group(P < 0.05).3.Comparison of objective symptom scoresObjective symptom scores and total objective symptom scores in two groups were compared(P < 0.05),both groups could improve objective symptoms;Comparing the scores of objective symptoms between the two groups,the improvement of desquamation,hyperpigmentation,telangiectasia and vellus hair growth in the two groups is similar 2 weeks after treatment(P > 0.05).In terms of erythema,acne papules,and swelling(P < 0.05),the improvement of the treatment group was better than that of the control group(P < 0.05).At 4 weeks after treatment,the improvement of erythema,hyperpigmentation,telangiectasia,and vellus hair growth was similar(P > 0.05).In terms of desquamation,acne,and swelling(P < 0.05),the improvement in the treatment group was better than in the control group(P < 0.05).At 8 weeks after treatment,the improvement of telangiectasia and vellus hair growth was similar(P > 0.05).The improvement of erythema,desquamation,pigmentation,acne papules,and swelling in the treatment group was better than that in the control group(P < 0.05).At 12 weeks after treatment,the improvement of desquamation,telangiectasia,and vellus hair growth was similar(P > 0.05).The improvement of erythema,pigmentation,acne,and swelling in the treatment group was better than that in the control group(P < 0.05).Comparing the total objective symptom score between the two groups,the improvement of objective symptoms in the two groups was as follows: 2 weeks,4 weeks,8weeks,and 12 weeks after treatment,the treatment group was better than the control group(P < 0.05).4.Comparison of dermatological quality of life scoresA comparison of skin disease quality of life scores between the two groups(P < 0.05)showed that skin disease quality of life could be improved in both groups.At 2 weeks and4 weeks after treatment,the improvement of skin disease quality of life score was similar between the two groups(P > 0.05).Comparison of skin disease life quality scores at 8weeks and 12 weeks after treatment showed improvement: the treatment group was better than the control group(P < 0.05).5.Analysis of the efficacy of skin lesionsAt 2 weeks,4 weeks,8 weeks,and 12 weeks after treatment,there was no significant difference in the total effective rate between the two groups(P > 0.05),suggesting that the total effective rate of the two groups was similar at 2 weeks,4 weeks,8 weeks and 12 weeks after treatment.At 4 weeks after treatment,the apparent efficiency was significantly different(P < 0.05),suggesting that the apparent efficiency in the treatment group was higher than that in the control group at 4 weeks after treatment.There was a significant difference in the recovery rate of skin lesions at 8 weeks and 12 weeks after treatment(P <0.05),suggesting that the recovery rate of skin lesions in the treatment group was higher than that in the control group at 8 weeks and 12 weeks after treatment.6.Safety index analysisThere were no significant differences in blood routine,liver function,and renal function between patients before treatment and 12 weeks after treatment(P > 0.05).The results indicated that there were no significant changes in blood routine,liver function,and renal function after treatment.Conclusion:1.Oral Chinese medicine Angelica Dizhu Decoction combined with external application of berberine hydrochloride oil in the treatment of facial hormone-dependent dermatitis with blood deficiency and wind-dryness syndrome,after 2 weeks of treatment,the improvement of objective symptoms was significantly better than the external application of berberine hydrochloride oil alone;After 4 weeks of treatment,the improvement of symptoms and the efficiency of skin lesions were better than that of berberine hydrochloride oil alone.After 8 weeks of treatment,the quality of life and recovery rate of skin lesions were significantly better than that of berberine hydrochloride oil alone.2.Oral Chinese medicine Angelica Dizhu Decoction combined with topical berberine hydrochloride oil to treat facial hormone-dependent dermatitis with blood deficiency and wind-dryness syndrome,and the TCM syndrome was improved after 2 weeks of treatment;The facial hormone-dependent dermatitis of blood deficiency and the wind-dryness syndrome were treated with berberine hydrochloride oil alone.After 8 weeks of treatment,the TCM syndrome was improved.3.After 12 weeks of treatment,the blood routine,liver function,and renal function test results of patients in the treatment group and the control group had no significant changes.In summary,compared with the external use of berberine hydrochloride oil alone,oral Chinese medicine Angelica Dizhu Decoction combined with external use of berberine hydrochloride oil in the treatment of facial hormone-dependent dermatitis with blood deficiency and wind dryness,has a faster effect,a shorter course of treatment,good safety,and better clinical efficacy,which is worthy of clinical promotion. |
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