Clinical Observation On The Treatment Of Gouty Arthritis Of Damp Heat Accumulation Type With Tongfeng Granule

Objective:By observing the clinical efficacy of Tongfeng Granule in the treatment of gouty arthritis with damp heat accumulation and evaluating its safety,it provides a theoretical basis for the treatment of gouty arthritis by traditional Chinese medicine.Methods:From March 2022 to December 2022,64 patients with gout arthritis who met the inclusion criteria were selected from the orthopedic outpatient department of the People’s Hospital affiliated to Fujian University of Traditional Chinese Medicine.Randomized number table method was used to group 32 cases in control group and 32 cases in experimental group.The following 3 courses of treatment were used.The treatment plan was as follows:the control group,the first course of treatment:Celecoxib capsule 0.2g bid,7 days;The second course of treatment:Celecoxib capsule 0.2g bid,feprista tablets 40 mg qd,7 days;The third course of treatment:feprista tablets 40 mg qd,14 days.The experimental group,the first course of treatment:Tongfeng granule 1 dose bid,7 days;The second course of treatment:Tongfeng granule 1 dose bid,feprista tablets 40 mg qd,7 days;The third course of treatment:fepristal tablets 40 mg qd,14 days.Record VAS scores,blood uric acid(UA),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP)before and after treatment for 1,2,and 4 weeks,as well as the TCM syndrome score before and after treatment.And during the treatment period,the time of pain relief,the number of gout recurrences,safety indicators,and the effect of TCM syndrome after treatment.Through statistical analysis,the clinical efficacy and safety of Tongfeng granules were evaluated.Results:1.VAS score:After 1 week,2 weeks and 4 weeks of treatment,VAS score in both groups decreased compared with that before treatment(P<0.05),and there was no significant difference between the two groups after 1 week,2 weeks and 4 weeks of treatment(P>0.05).2.Pain relief time:There was no significant difference between the two groups(P>0.05).3.Number of gout recurrence:during the treatment,the recurrence rate of the control group was 34.38%,and the recurrence rate of the test group was 9.38%.The recurrence rate in the test group was lower than that in the control group(P<0.05).4.Laboratory indicators:UA,ESR and CRP in both groups decreased with time,and the effect of reducing UA in the test group was better than that in the control group after 4 weeks of treatment(P<0.05);After 2 and 4 weeks of treatment,the effect of ESR reduction in the test group was better than that in the control group(P<0.05);There was no significant difference in CRP between the two groups at each observation time point(P>0.05).5.TCM syndrome score:After 4 weeks of treatment,the TCM syndrome score of both groups was improved,and the improvement effect of the test group was better than that of the control group(P<0.05).6.The effect of TCM syndrome:The total effective rate of the control group was87.5%,and the total effective rate of the test group was 93.75%.The effect of the test group was better than that of the control group(P<0.05).7.Safety: the blood routine test,liver and kidney functions of the two groups of patients were tested before treatment and 1 and 4 weeks after treatment,and there were no obvious abnormalities.During the treatment,the patient’s vital signs were stable,and there were no gastrointestinal reactions,rashes,allergies and other adverse reactions.Conclusion:Tongfeng Granule has a significant therapeutic effect on traditional Chinese medicine syndromes of gouty arthritis with dampness heat accumulation.It can alleviate joint pain,reduce CRP.Moreover,it is superior to the use of celecoxib capsules in reducing gout recurrence,reducing UA and ESR,and improving TCM syndromes,with good safety.