| Objective: By observing the clinical efficacy and safety of Qing-Heat,De-Dampness and Drainage Tang in the treatment of Damp-Heat type Long Qian(acute gouty arthritis),we provide a basis for the clinical use of Qing-Heat,De-Dampness and Drainage Tang in the treatment of Damp-Heat type Long Qian.Methods: Seventy-two cases of damp-heat type rungus from the Department of Rheumatology of Guangxi International Zhuang Medical Hospital who met the enrollment criteria were collected and divided into 36 cases in the control group and 36 cases in the observation group using the random number table method.The control group was treated orally with diclofenac sodium double-release enteric capsules,and the observation group was treated internally with heat-clearing and dampness-removing detoxification soup in combination with the treatment regimen of the control group.The clinical efficacy of clearing heat,removing dampness and detoxifying soup in the treatment of damp-heat type of rongguan was evaluated by observing the index changes of TCM evidence score,pain visual analog score(VAS),C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),blood uric acid(SUA),TCM evidence efficacy,liver function and kidney function in both groups before and after treatment,combined with statistical analysis.Results:(1)The differences in gender,age and disease duration between the two groups before treatment were not statistically significant(P > 0.05)and were comparable.(2)Pain VAS score: after treatment,the VAS scores of the two groups were lower than before treatment,and the difference was statistically significant(P < 0.05),and the difference was statistically significant(P < 0.05)when compared between the two groups after treatment,and the observation group was better than the control group.(3)Laboratory indexes: After treatment,CRP decreased in both groups compared with that before treatment,and the difference was statistically significant(P < 0.05),and after treatment,the difference between the two groups was statistically significant(P < 0.05),and the observation group was better than the control group.After treatment,ESR decreased in both groups compared with that before treatment,and the difference was statistically significant(P < 0.05),and the difference between the two groups after treatment was statistically significant(P < 0.05),and the observation group was better than the control group.After treatment,SUA decreased in both groups compared with that before treatment,and the difference was statistically significant(P < 0.05),and the difference between the two groups after treatment was statistically significant(P < 0.05),and the observation group was better than the control group.(4)Chinese medicine evidence points: after treatment,the Chinese medicine evidence points of the two groups decreased compared with those before treatment,and the difference was statistically significant(P < 0.01),and the difference between the two groups after treatment was statistically significant(P < 0.05).Among them,joint pain,swelling,skin temperature and mobility,the difference between the two groups after treatment was statistically significant(P < 0.05),and the observation group was better than the control group.Among them,thirst,heavy limb sleepiness,irritability and yellow urine,the difference between the two groups after treatment was statistically significant(P < 0.05),and the observation group was better than the control group.(5)Efficacy of Chinese medical evidence: in the observation group,34 cases,5 cases were clinically cured,16 cases were apparently effective,10 cases were effective,and 3 cases were invalid,with a total effective rate of 91.17%;in the control group,34 cases,1 case was clinically cured,14 cases were apparently effective,11 cases were effective,and 8 cases were invalid,with a total effective rate of 76.47%.There was a statistically significant difference(P < 0.05)in the efficacy of TCM symptoms between the two groups after treatment,and the observation group was superior to the control group.(6)Safety: Blood routine,urine routine,stool routine,liver function,kidney function,and electrocardiogram were in the normal range in both groups in the study.One adverse reaction occurred in the observation group,and the incidence of adverse reactions was 2.9%;3cases of adverse reactions occurred in the control group,and the incidence of adverse reactions was 8.8%.The degree of adverse reactions in the two groups was mild,and the difference between the two groups was not statistically significant(P>0.05).Conclusion(s): The combination of clearing heat and removing dampness and detoxifying soup with NSAIDs and treatment with NSAIDs alone improved clinical symptoms and signs,reduced CRP and ESR inflammatory indexes,and improved pain VAS scores and TCM evidence scores in both groups.However,compared with the treatment with NSAIDs alone,the group that used the Qinghe Dehumidification and Detoxification Soup for internal use had better clinical efficacy,could better improve the TCM evidence score,had a better effect in improving pain,could reduce the SUA level to some extent,had a low incidence of adverse effects,and had a good safety profile. |
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