Comparison Of Neuropsychology,Metabolism And Imaging Characteristics Between Alzheimer’s Disease And Parkinson’s Disease With Dementia

Objective:The present study aims to provide a basis for early diagnosis and early differentiation between Alzheimer’s Disease(AD)and Parkinson Disease with dementia(PDD).Methods:20 patients with AD and 20 patients with PDD admitted to the Department of Neurology,the Second Clinical Medical College of Jinan University from August 2020 to December 2021 were included.The demographic data,cognitive and neuropsychological scale scores,imaging,venous blood and cerebrospinal fluid results were recorded and analyzed using SPSS20.0statistical software for comparison and correlation analysis between groups.Results:There were significant differences between AD and PDD patients in the total score,memory,language,abstraction ability and orientation ability of Montreal Cognitive Assessment(P < 0.05),and correlated with the linear index of brain atrophy(P < 0.05).There were significant differences between AD and PDD patients in the total score of Pittsburgh sleep quality index,sleep duration,daytime dysfunction,the total score of Hamilton Anxiety Scale and Hamilton depression Scale,somatic anxiety factor.There was a linear correlation between different sleep disorder dimensions and cognitive domains and brain atrophy in the two groups(P < 0.05).There were significant differences in amount of Aβ1-42,Aβ1-42/Aβ1-40,P-Tau,T-Tau in cerebrospinal fluid,amount of homocysteine and triglyceride-glucose(Ty G)index in peripheral blood between AD and PDD patients(P < 0.05).There was a linear correlation between biomarkers and cognitive function,sleep disorder dimension and brain atrophy in both groups(P< 0.05).Conclusion:There are significant differences between AD and PDD in cognitive impairment,affective sleep disorder and biomarkers in cerebrospinal fluid and peripheral blood.Memory disorder is the main clinical symptom in AD patients,while in PDD patients,sleep disorder,anxiety and depression disorder are more prominent.Aβ1-42/Aβ1-40 and Ty G index have certain clinical significances in the differential diagnosis of disease with cognitive impairment.