Correlation Analysis Between Parkinson’s Disease Dementia And Neurofilament Protein Level

Objective 1.to analyze the levels of urinary Alzheimer’s disease-associated neurofilament egg(AD7c-NTP)in Parkinson’s disease with dementia(PDD),Alzheimer’s disease(AD),and Vascular dementia(VD),and to clarify its diagnostic value.Vascular dementia(VD),and to clarify its diagnostic value for PDD,AD,and VD.2.To investigate the characteristics of cognitive impairment in patients with PDD,AD,and VD.Methods Fifty patients diagnosed with PD in the outpatient and inpatient departments of the Department of Neurology of Ningxia Medical University General Hospital from January 2021 to December 2022 were collected and divided into two groups according to the presence or absence of dementia,including 30 patients in the PDD group and 20 patients in the PD without cognitive impairment(PDNCI)group,30 patients with AD,27 patients with VD,and 24 healthy controls were chosen during the same period.General information of all enrolled patients was collected,and PD patients were also collected for first symptoms,disease duration,type of motor impairment,medication,UPDRS part III score,and H&Y classification;all enrolled patients were evaluated for cognitive function using MMSE and Mo CA-B scale scores;all subjects were retained for the detection of AD7C-NTP levels in case of randomized mid-stage urine.Results1.By comparing urinary AD7c-NTP levels in the PDD group,PDNCI group,AD group,VD group and HC group,it was found that there was a significant difference(P<0.05)in the comparison of AD7c-NTP levels between the five groups,and a significant difference(P<0.05)was found between the PDD group and PDNCI group,AD group and PDNCI group,and AD group and VD group when compared between the two groups.group compared with PDNCI group,HC group compared with VD group,PDD group compared with AD group,and PDD group compared with VD group were not significantly different(P>0.05).2.Spearman correlation analysis was performed on urine AD7c-NTP level and clinical variables in PD patients,and it was found that there was a significant positive correlation between urine AD7c-NTP level and H&Y grade in PDD group(r>0,P<0.05),and the higher the H&Y grade,the higher the urine AD7c-NTP level.There was a significant negative correlation between urine AD7c-NTP levels and MMSE and Mo CA-B scores in PDD group and PDNCI group(r<0,P<0.05),that is,the lower the MMSE and Mo CA-B scores,the higher the urine AD7c-NTP level.3.The area under the ROC curve(AUG)of urinary AD7c-NTP level to predict PDD,AD,and VD were 0.772,0.817,0.675,respectively,suggesting that urinary AD7c-NTP level had the greatest predictive value for AD.4.For cognitive assessment,there were significant differences in MMSE and Mo CA-B scores between the five groups of PDNCI group,PDD group,AD group,VD group and HC group(P > 0.05),and a two-by-two comparison revealed that there were significant differences in MMSE and Mo CA-B scores between AD group and VD group,PDD group and VD group(P < 0.05),and the difference between AD group and PDD group was not When the MMSE scores of patients in the PDD,AD,and VD groups were compared,there were significant differences in orientation,memory,attention and computation,and recall scores(P< 0.05),and in Mo CA-B scores of cognitive domains,there were significant differences in orientation,computation,abstract thinking,delayed recall,and visual perception scores between the three groups(P < 0.05).Conclusion1.The worse the cognitive function of PDD patients,the higher the H & Y grade,and the higher the urinary AD7c-NTP level.2.AD7c-NTP level has predictive value for PDD,AD and VD,but has the greatest predictive value for AD.3.Patients with PDD,AD and VD all had extensive cognitive impairment,and AD and VD patients had significant impairments in orientation,memory,attention and calculation,abstract thinking,and recall ability than patients with PDD.