Study On The Relationship Between REM Sleep Behavior Disorder And Cognitive Function In Parkinson’s Disease

Objective:To explore the relationship between REM sleep behavior disorder and cognitive function in Parkinson’s disease Methods:44 patients with PD were included into this study,who visited the China and Japan union hospital of Jilin university during 2014 to 2017.we recorded the patients’ demographics date including age,sex,education years and we also recorded the patients’ clinical data including disease course,motor symptoms,non-motor symptoms.44 patients were divided into PD-RBD group(n = 23)and PD-NRBD group(n = 21)according to the RBD screening scaling questionnaire(RBDQ-HK).All subjects underwent a unified PD rating scale,Part III(UPDRS-III)to assess motor symptoms.Evaluation of the severity of PD motor symptoms by Hoehn-Yahr(H-Y)stage.(MMSE)and the Montreal Scale(Mo CA)were used to evaluate the global cognitive.Digit Span Forward,and Digit Symbol were used to evaluate the attention.Stroop Color-Word Test(CWT)and the Trail Making Test(TMT)to evaluate the executive function.The visual function was evaluated by the 30-point scale of The Clock Drawing Test.The language was evaluated by Verbal Fluency Test(VFT)and the Boston name test.The memory was evaluated using the Rey auditory language learning test.The above evaluation tools were performed by the neurosurgery professional physician to complete the clinical symptoms,cognitive function,and use the statistical method to compare.Result:The age,sex,educational years,disease course and motor symptoms were showed no statistical significance difference between RBD group and non RBD group(P>0.05).(MMSE)and the Montreal Scale(Mo CA)were showed statistical significance difference between RBD group and non RBD group(P<0.05).The Symbol Digit Modalities Test,Stroop Color-Word Test,Trail Making Test,the Clock Drawing Test,Boston name test,word fluency(fruit)scores were showed statistical significance difference between RBD group and non RBD group(P<0.05).There were also significant differences in gastrointestinal digestive function,autonomic nerve function,neuropsychiatric symptoms and sleep status between RBD group and non RBD group(P<0.05).Conclusion:Through the comparison of PD-RBD patients and PD-NRBD patients,RBD can affect PD patients on its comprehensive cognitive function to a certain degree.At the same time,there was a certain degree of influence in the cognitive field such as executive function,visuospatial function,language function and attention.The RBD also affects the gastrointestinal digestive function,autonomic symptoms,neuropsychiatric symptoms,sleep disorders and other aspects of PD patients with nonmotor symptoms.