| ObjectiveThe purpose of this study was to observe the clinical efficacy of Jiawei Pingwei Powder in the treatment of obesity with spleen deficiency and phlegm-dampness in prediabetes.Provide reliable and effective solutionsMethodsA randomized controlled study method was used.According to the inclusion criteria,70 obese patients with prediabetes with spleen deficiency and phlegm dampness were divided into an observation group and a control group according to the random number table method.On the basis of health education,the control group was given conventional western medicine(hydrochloric acid)Metformin tablets),observation group(combination therapy with Jiawei Pingwei powder + metformin hydrochloride tablets),the course of treatment was 3 months.The changes of FPG,2h PG,FINS,HOMA-IR,TC,TG,BMI,Hb A1 C,and TCM syndrome scores in the two groups before and after treatment were observed,and statistical analysis was performed by SPSS 20.0 statistical software to objectively evaluate the treatment of spleen deficiency and phlegm-dampness by Jiawei Pingwei Powder.Safety and efficacy in obese patients with prediabetes.Results1.A total of 70 patients were included in this study,and a total of 64 patients completed clinical observation and were included in the statistics.3 patients in the control group dropped out,and 3 patients in the observation group dropped out,with a total dropout rate of 8.57%.2.Before treatment,there were no significant differences in gender,age,BMI,FPG,2h PG,FINS,HOMA-IR,TC,TG,BMI,Hb A1 C,and TCM syndrome scores between the two groups(P>0.05),which were comparable.3.After treatment,the overall curative effects of the two groups were compared.The total effective rates of the control group and the observation group were 62.5% and 84.38%,respectively.The curative effect of the observation group was higher than that of the control group,and the difference was statistically significant between the two groups after treatment(P<0.05).4.Comparison of body mass index: After treatment,the BMI levels of the control group and the observation group were both lower than those before treatment(P<0.05),and the curative effect of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).5.Comparison of blood lipid levels: TC and TG were improved before and after treatment in the two groups,and the difference was statistically significant(P<0.05).In terms of TG indicators,there was no significant difference between the two groups after treatment(P>0.05).6.Comparison of blood glucose levels: In terms of FPG index,the difference between the two groups before and after treatment was significant(P<0.05),and the observation group was better than the control group,with a statistically significant difference(P<0.05).Compared with before,the difference was statistically significant(P<0.05),but there was no significant difference between the two groups after treatment(P>0.05).7.Comparison of insulin levels: after treatment,FINS and HOMA-IR in the two groups were significantly lower than those before treatment,and the difference was statistically significant(P<0.05);and the observation group was lower than the control group,and the difference between the two groups was statistically significant(P<0.05).);.8.The improvement rate of TCM clinical symptoms: 4 cases in the observation group were cured,9 cases were markedly effective,16 cases were effective,3 cases were ineffective,and the effective rate was 90.63%;Efficiency 65.63%,there is a significant difference in component comparison(P<0.01).9.The safety-related laboratory indicators of the two groups were analyzed,and there was no significant difference before and after treatment(P>0.05).ConclusionJiawei Pingwei Powder combined with metformin can improve the clinical symptoms of obese prediabetic patients with spleen deficiency and phlegm dampness syndrome,improve the quality of life,reduce body weight,increase insulin sensitivity,regulate blood sugar and blood lipid levels,and the efficacy is better than metformin alone,with good safety.No obvious adverse reactions. |
