Study On The Associations Between Abnormal Lipid Metabolism And Prostate Cancer

Objective:To analyze the risk factors of prostate cancer and to investigate the associations of obesity,triglyceride,cholesterol and lipoprotein levels with the occurrence and progression of prostate cancer,and to provide some clinical evidence for the prevention,screening and diagnosis of prostate cancer.Methods:Collected the clinical data of male patients underwent prostate surgery(including TURP,biopsy,radical prostatectomy)at the Second Hospital of Tianjin Medical University urology department from October 2018 to October 2019,including age,body mass index,prostate specific antigen,blood glucose,triglyceride,cholesterol,high-density lipoprotein,low density lipoprotein,pathological diagnosis and Gleason scores.Statistical software was used to analyze and compare the differences between the prostatic hyperplasia group and the prostate cancer group,and between the high-grade PCa group and the non-high-grade PCa group,using univariate and multivariate logistic regression analysis and spearman correlation analysis.P < 0.05 was considered statistically significant.Results:A total of 299 patients were included in this study,including 187 cases of BPH(62.5%),112 cases of PCa(37.5%),46 patients cases of non-high-grade PCa,and 66 cases of high-grade group.The mean age,PSA,obesity and high TC ratio in the PCa group were significantly higher than that in the BPH group(P < 0.05).There were no significant differences in BMI,GLU,TG,HDL,LDL and other factors between the two groups(P > 0.05).Multivariate logistic regression analysis showed that age(OR: 1.105,95% CI: 1.029-1.185),PSA(OR: 1.370,95% CI: 1.236-1.486),and obesity(OR: 2.395,95% CI: 1.013-5.663)were independent risk factors of PCa(P < 0.05).The mean PSA,obesity and low HDL ratio in the high-grade PCa group were significantly higher than those in the non-high-grade group(P < 0.05).There were no significant differences in age,BMI,GLU,TC,TG,HDL,LDL and other factors between the two groups(P > 0.05).Multivariate logistic regression analysis showed that PSA(OR: 1.087,95% CI: 1.043-1.132),obesity(OR: 2.715,95% CI: 1.062-6.942)and low HDL(OR: 3.380,95% CI: 1.115-10.245)were independent risk factors of high-grade PCa(P < 0.05).Spearman correlation analysis showed that Gleason score was positively correlated with age(r: 0.234,p: 0.013)and BMI(r: 0.190,p: 0.044),and negatively correlated with HDL(r:-0.154,p: 0.037).Conclusion:1.Obesity is an independent risk factor for PCa and high-grade PCa,and the Gleason score is positively correlated with BMI.2.Hypercholesterolemia was significantly different between the PCa and BPH group,but was not a risk factor for the development and progression of PCa.3.Low HDL is an independent risk factor for high-grade PCa,and the Gleason score is negatively correlated with HDL.4.Triglycerides and LDL are not risk factors for PCa.