The Relationship Between Obesity And Blood Lipids In The Occurrence And Progression Of Prostate Cancer

Objective To research the risk factors of prostate cancer occurrence and progression,and to explore the relationship between obesity,blood lipids and lipoprotein and prostate cancer,and to provide appropriate reference for the clinical diagnosi s and treatment of prostate cancer.Methods Retrospective study of medical records of patients undergoing transrecta l prostatic biopsy guided by B-ultrasonography during the period from January 2013 to November 2016 in the First Affiliated Hospital of Xiamen University.Thr ough the Xiamen University First Affiliated Hospital electronic patient records sy stem to collect detailed clinical data,and puncture pathology results and other da ta.Using single factor and multivariate logistic regression analysis and spearman rank correlation analysis,the standard was P <0.05.Result A total of 428 patients underwent transrectal biopsy guided by rectal ultra sonography,postoperative pathology was diagnosed as non-prostate cancer in 255cases(59.6%),173 cases of prostate cancer(40.4%),The median value of PSA a nd Mean age in the prostate cancer group was higher than that in the nonprostat e cancer group.There was significant difference between the two groups(P <0.05).There was no significant difference in height,body weight,blood glucose an d blood lipid and lipoprotein(P>0.05).In the prostate cancer group,obese peop le,smoking history,history of hypertension,hypercholesterolemia compared with non-prostate cancer group,there was a significant difference(P <0.05).Two group s of patients in the history of drinking,diabetes history,high triglyceride,high a nd low density lipoproteinemia and other aspects of no significant difference(P>0.05).Univariate unconditional logistic regression analysis showed that age,obesity,smoking,hypertension,hypercholesterolemia,PSA may be a risk factor for punc ture-positive prostate cancer(P <0.05).Multivariate logistic regression analysis show ed that age,smoking,hypertension,PSA,and obesity were independent risk fact ors for puncture-positive prostate cancer(P <0.05).Logistic regression analysis of h igh-risk and non-high-risk group of prostate cancer results in obesity,PSA is an independent risk factor for high-risk prostate cancer,the difference was statisticall y significant.Apolipoprotein A1 is a protective factor for high-risk prostate cancer,which is statistically significant(P <0.05).3.The correlation between obesity and clinical stage of prostate cancer and the Spearman grade of Gleason score showe d that there was a negative correlation between clinical stage T and high density lipoprotein in prost-ate cancer and negatively correlated with apolipoprotein A1;The negative corr-elation between Gleason score and high density lipoprotein and apolipoprotein A1 in prostate cancer;Body mass index was positively correlated with Gleason score and was not associated with clinical stage of prostate cancer.4.Logistic regression analysis of prostate cancer bone metastases showed that lip oprotein a and Gleason scores may be a risk factor for bone metastases of prost ate ca-ncer,the difference was statistically significant(P <0.05).Conclusion Age,smoking,obesity is an independent risk factor for prostate c-an cer.Patients with prostate cancer and non-prostate cancer differ in cholesterol leve ls,but not with triglycerides,high density lipoprotein,low density lipoprotein,ap olipoprotein,etc.are not prostate cancer risk factors.2.Obesity is an independent risk factor for high-risk prostate cancer and Apolipoprotein A1 is a protective fac tor for high-risk prostate cancer.3.High density lipoprotein,apolipoprotein A1 and prostate cancer staging,Gleason score was negatively correlated;Obesity was p ositively correlated with Gleason score of prostate cancer.4.Gleason score is an in dependent risk factor for prostate cancer bone metastases,and it can not be cons idered obesity,dyslipidemia is a risk factor for prostate c-ancer bone metastases.