Study On The Relationship Between Serum Lipid Levels And The Risk Of Low-Grade,Intermediate-Grade And High-Grade Prostate Cancer In Plateau Areas

Objective: To investigate the correlation between serum lipid levels and high-grade,intermediate-grade and low-grade prostate cancerMethods: A database was established in an Excel table,and SPSS 22.0 was used to process and analyze the data.The unordered categorical data were expressed by the number of cases and percentages.The comparison between groups was performed by one-way analysis of variance,and R*C table chi-square test(two-way unordered).Continuous Serum Cholesterol(TC),Serum Triglyceride(TG),Serum Low Density Lipoprotein Cholesterol(LDL-C),Serum High Density Lipoprotein Cholesterol(HDL-C)and Low Prostate Cancer(Pca)Using Spearman Correlation Analysis Whether there is a linear trend between levels,medium,and high levels.Then multivariate logistic regression analysis was used to test serum total cholesterol(TC),serum triglyceride(TG),serum low-density lipoprotein cholesterol(LDL-C),serum high-density lipoprotein cholesterol(HDL-C)and prostate cancer.(Pca)Correlation strength between low,medium,and high grades.The maximum likelihood ratio estimate,95% confidence interval and P value of OR were calculated,and the significance test standard a=0.05.Adjusted for age at baseline(continuous),serum total cholesterol,serum triglycerides,serum LDL-C,serum HDL-C(continuous data),body mass index(BMI)and prostate-specific antigen(PSA)(continuous data),family history Prostate cancer(yes,no),smoking status(smoked,never),drinking history(drinked,never).Results: Univariate analysis results of serum total cholesterol(TC,OR=1.581,95%CI: 1.300-1.921,P<0.001),serum triglyceride(TG,OR=1.608,95%CI: 1.047-2.417,P= 0.030),serum low-density lipoprotein cholesterol(LDL-C,OR=1.505,95%CI: 1.118-2.027,P=0.007),family history of tumor(OR=1.831,95%CI: 1.085-3.090,P=0.024)),smoking history(OR=1.671,95%CI: 1.028-2.718,P=0.039),body mass index(BMI,OR=1.725,95%CI: 1.314-2.265,P<0.001)were all related to high-grade prostate cancer,medium-level risk factors(all P < 0.05).And age(OR=1.013,95%CI: 0.987-1.040,P=0.343),TPSA(OR=0.999,95%CI:0.981-1.017,P=0.897),serum HDL-C(OR=1.008,95%)CI: 0.509-1.998,P=0.981),drinking history(OR=1.134,95%CI: 0.716-1.799,P=0.592)were not significantly associated with high-grade and intermediate-grade prostate cancer risk(all P>0.05).The above-mentioned factors with statistical significance in the univariate analysis results of high-grade and intermediate-grade risk of prostate cancer were incorporated into the multivariate logistic regression analysis model.The results showed that serum total cholesterol(TC,OR=1.898,95%CI: 1.458-2.470,P<0.001),serum low-density lipoprotein cholesterol(LDL-C,OR=1.981,95%CI: 1.342-2.923,P=0.001),family history of tumor(OR=2.150,95%CI: 1.071-4.316,P =0.031).Body mass index(BMI)was used as a dummy variable,and patients with normal BMI had a lower risk of high-grade prostate cancer than those with lean BMI(OR=0.384,95%CI: 0.170-0.868,P=0.021);BMI Overweight patients had higher risk of high-grade prostate cancer than those with lean body mass index(OR=4.485,95%CI: 2.016-9.974,P<0.001);obese patients with BMI had no higher risk than those with lean body mass index.Statistical difference(OR=1.185,95%CI: 0.430-3.265,P=0.743)were independent risk factors for high-grade and intermediate-grade prostate cancer(all P<0.05),as shown in Table4.Although no relationship was found between elevated serum triglycerides and an increased risk of high-grade prostate cancer(OR=1.687,95%CI: 0.988-2.880,P=0.055),the mean serum triglycerides in intermediate-grade patients(M=1.2614)was lower than the mean of high-grade serum triglycerides(M=1.3997),reaching marginal statistical significance.Serum triglycerides and smoking history(OR=0.805,95%CI: 0.437-1.484,P=0.487)are not independent risk factors for high-grade and intermediate-grade prostate cancer,but they can still be used as predictors of high-grade and intermediate-grade prostate cancer An important reference indicator of risk.Conclusion: Serum TC,serum LDL-C,family history of tumor and body mass index are independent risk factors for high-grade and intermediate-grade prostate cancer.Serum triglycerides and smoking history are not independent risk factors for high-grade and intermediate-grade prostate cancer,but they can still be used as important reference indicators for predicting the risk of high-grade and intermediate-grade prostate cancer.