Clinical Experience Of Professor Wang Fengyun In Treating Gastroesophageal Reflux Disease Based On Data Mining

Objective:With the help of ancient and modern medical case cloud platform,data mining method was used to analyze the commonly used drugs,compatibility characteristics and core prescriptions of professor Wang Fengyun’s clinical diagnosis and treatment of gastroesophageal reflux disease,and summarize her clinical experience.Materials and Methods:A total of 698 cases of GERD patients treated by my tutor in the Gastroenterology Department and Special Service Department of Xiyuan Hospital,China Academy of Chinese Medical Sciences from February 2019 to January 2021 were selected.The general information,clinical symptoms,TCM syndrome and TCM prescription of patients were collected to establish the database.Use the ancient and modern medical case cloud platform to conduct statistical analysis,association rule analysis,cluster analysis and complex network analysis of standardized data.Results:1.General data statistics:among the 698 patients in this study,males accounted for 36%and females accounted for 64%,indicating a significant difference between males and females.Analysis of age showed that the largest number of patients were between 50 and 70 years old.2.Clinical symptom statistics:A total of 131 clinical symptoms were obtained,among which acid reflux(411 times)and heartburn(364 times)were the most frequent.In addition,abdominal distention,belching,nausea,noise,bad mood,bad throat,thin stools,poor sleep,dim pain after esophagus,stuffy stomach,dry stool,back pain,stomachache,dry mouth,foreign body sensation in the throat,bitter mouth,chills and other symptoms are also common symptoms.3.Tongue and pulse statistics:the most frequent tongue types were light tongue(300),red tongue(252)and light tongue red tongue(122),followed by fat tongue,dark tongue and light tongue tooth marks.The main types of tongue coating were thin(372),greasy(349)and yellow(167).Pulse patterns were more common in chord(404),thin(285),smooth(223)and fast(178).4.TCM syndrome type analysis:Finally got eight kinds of TCM syndrome types,respectively muggy syndrome(164),liver stomach qi depression phlegm syndrome(120),hot and humid pixu(spleen deficient)certificate(116),virtual reversed flow of qi in the certificate(109),gallbladder heat make stomach syndrome(91),liver stomach with(59),fever syndrome(27),mixed blood stasis resistance collaterals syndrome(12).5.The highest frequency of TCM treatment was Hewei Jiangni(348)and Jianpi Hewei(218),followed by Shugan Xiehe(174)and Shugan Liqi(148).In addition,there are a variety of treatment methods,such as reducing Qi and resolving phlegm,relieving depression and stomach,clearing away damp heat,Clearing Away Gallbladder Heat,calming cold and heat,regulating qi and relieving pain,promoting blood circulation and removing blood stasis.6.Drug use frequency analysis:get 167 taste traditional Chinese medicine(TCM),a high frequency of rhizoma coptidis(627),cuttlefish bone(613),the system of evodia rutaecarpa(603),dried tangerine or orange peel(555),zhejiang fritillary(534)(504),vinegar green husk,Fried gardenia(503),stem(469),cortex moutan(405),fry Perilla(390),calcined ocher(328),etc.7.Analysis of the nature,taste and meridian tropism of traditional Chinese medicine:warm and cold drugs were the most commonly used drugs,followed by mild and mild cold drugs;Bitter,pungent and sweet are the main flavor;The main channel of drugs was spleen,stomach and lung,followed by liver,heart and kidney,while the small intestine and pericardium were less.8.Analysis of the efficacy of traditional Chinese medicine:the efficacy of traditional Chinese medicine is mainly to clear heat,dry and dry wet,reduce the anti nausea,dry wet phlegm,make acid and relieve pain,moisten the intestines and relieve the bowel and relieve the stool,and the frequency of the occurrence of Qi Strengthening,reducing Qi and phlegm,and clearing liver and breaking Qi is also higher.9.Correlation analysis of traditional Chinese medicine:the confidence was set to 0.8,the support was set to 0.5,the combination of support≤1 was eliminated,and the commonly used drug combinations were Coptis rutaecarpus,cuttlebone Fritillaria thunbergii,tangerine peel vinegar green peel,etc.Correlation analysis of TCM syndromes and traditional Chinese medicine:the confidence was set to 0.8,the support was set to 0.06,and the data of promotion degree≤1 were excluded.The results showed that Coptis chinensis,Evodia rutaecarpa,cuttlebone had a high correlation with each syndrome,Ganwei yure syndrome had the highest promotion degree with Gardenia jasminoides Ellis,and gallbladder heat invading stomach syndrome had a high correlation with Qingpi and Chenpi.10.Cluster analysis:Two groups of results were obtained by cluster analysis of the top 20 traditional Chinese medicines with the most frequent occurrences:(1)Persimmon stem,calcined ochres,fried gardenia,peony peel,tangerine peel,vinegar green peel,coptis coptidis,prepared Cornus officinalis,cuttlebone,and fritillaria thunberg;(2)bamboo shavings,vinegar,ginger,vinegar husuo,safflower,fried Perilla seed,fried bitter almond,Dangshen,bran fried hawthorn,Magnolia officinalis.11.Complex network analysis:Through complex network analysis,eight core traditional Chinese medicines commonly used by my tutor were obtained:coptis chinensis,evodia rutensis,cuttlebone mantidis,thunberg fritilla,tangerine peel,vinegar green peel,fried gardeniafFructus,and persimmonia fructus,which could be used as my tutor’s core prescription for the treatment of GERD.Conclusions:My tutor thinks that gastroesophageal reflux disease is located in the esophagus and stomach,and the causes of the disease are mostly due to improper diet,emotional disorders,and weakness of the spleen and stomach.The basic mechanism of the disease is the inverse of stomach qi,which is related to the unease of liver qi,unhealthy temper,and the rapid decline of lung.Clinical treatment is often to regulate the Qi machine,pay attention to the patient’s mood,care for the stomach Qi,the overall use of TCM is appropriate.