Clinical Study On Moxibustion At Zusanli And Other Points To Prevent Vomiting After Chemotherapy For Gastric Cancer

Objective: By observing the clinical efficacy of moxibustion at Zusanli and other points in preventing and treating nausea and vomiting after chemotherapy for advanced gastric cancer,this paper studies the clinical application value and safety of this method,and provides clinical basis for TCM clinical thinking of moxibustion in preventing and treating nausea and vomiting after chemotherapy.Methods: Following the principle of randomization and reducing bias,60 patients were randomly divided into control group and observation group with30 in each group.All patients in the control group were given routine antiemetics 30 minutes before chemotherapy.On the basis of the control group,the observation group was given moxibustion at Zusanli,Neiguan and Zhongwan for 20 minutes before chemotherapy.Continuous treatment for 8 days.At the end of a course of treatment,evaluate the curative effect scores and total scores,KPS scores,scores of other related symptoms of gastrointestinal tract and changes of safety indicators at different time points before and after chemotherapy,and judge and evaluate the relief effect of nausea and vomiting and other related symptoms of gastrointestinal tract after treatment.Results: 1.Comparison of nausea and vomiting symptom scores at different time points: There was no significant difference between the two groups on the first day after chemotherapy(P > 0.05);On the 4th day after chemotherapy,the scores of nausea and vomiting in both groups increased,and the nausea and vomiting in the control group was more serious than that in the observation group(P < 0.05).On the 8th day after chemotherapy,the scores of nausea and vomiting in both groups decreased,and the symptoms in the observation group were lighter than those in the control group(P < 0.05).There is a difference in the overall score between the two groups(P < 0.05).2.Comparison of KPS scores of patients at different time points: On the 4th day after chemotherapy,KPS scores of both groups decreased,and the scores of observation group were better than those of control group,but there was no statistical difference(P > 0.05).On the 8th day after chemotherapy,KPS scores of both groups began to rise,and the scores of observation group were better than those of control group(P < 0.05).The KPS score of the observation group decreased less than that of the control group before and on the 4th day after chemotherapy(P < 0.05).On the 4th and 8th days after chemotherapy,the KPS score in the observation group was higher than that in the control group(P < 0.05).3.Comparison of scores of other related symptoms of gastrointestinal tract:The symptoms of pantothenic acid,anorexia,constipation and fatigue in the observation group were lighter than those in the control group(P < 0.05).However,there was no difference in relieving symptoms such as stomachache and bloating(P > 0.05).4.Comparison of safety indicators: WBC value of observation group was higher than that of control group(P < 0.05);There was no statistical difference between the two groups in other groups(P > 0.05).Conclusion:Moxibustion at Zusanli and other points can effectively prevent and treat nausea and vomiting after chemotherapy for advanced gastric cancer,improve KPS scores of patients after chemotherapy,improve other related symptoms of gastrointestinal tract of patients,and relieve bone marrow suppression caused by chemotherapy without side effects,which is worth popularizing.