| Objective:Observe the clinical efficacy of Fangfengtongshengsan Modified and Subtracted Recipe in the treatment of psoriasis vulgaris,as well as the improvement of patients’ symptoms and the effect on serum CRP levels and IL-17A levels.Methods : Patients with 80 cases of psoriasis were divided into treatment groups and control groups according to the random digital table.Forty patients in the treatment group were treated with Fangfeng Tongsheng powder orally;40 patients in the control group were treated with compound aminopeptide tablets orally.The PASI score changes of the patients were evaluated at the 4th week and the 8th week after treatment,and the TCM syndrome scores before and after treatment and the serum CRP and IL-17A levels were statistically analyzed.Results:A total of 80 cases were included in which 1 case was detached and finally completed 79 cases of treatment,40 cases of treatment group,39 in control group.The results were obtained as follows:(1)There is no statistical significance between the age,gender and diseased processes of the two groups(P>0.05),the skin damage area before the treatment,PASI rating,Chinese medicine symptoms,serum CRP and IL-17A levels have no obvious Differences have comparability(P>0.05).(2)Percentage of skin lesion area:The percentage of skin lesion area before treatment in the treatment group was(18.75±14.43)%,and after treatment it was(10.80±9.53)%;The control group was(21.23 ± 15.95)% before treatment and(15.95 ± 12.71)% after treatment;Before and after treatment,the difference between the two groups was statistically significant(P<0.05).The treatment group was better than the control group in reducing the area of skin lesions(P < 0.05).(3)PASI score comparison: The average PASI scores of the treatment group before treatment,after the 4th week of treatment,and after the 8th week were(13.57±1.86),(6.75±4.24),(6.05±3.77)points,and the control group were(13.86± 2.27),(11.09 ± 3.86),(8.03 ± 9.82)points;After 4 weeks of treatment,the PASI scores of the two groups were lower than before treatment(P<0.05),and the decrease in the treatment group was more significant(P<0.05).After the 8th week of treatment,there was no significant difference in the PASI score of the treatment group from the 4th week(P>0.05).The control group was significantly lower than the 4th week(P<0.05),The treatment group had more advantages in reducing the PASI score during the whole treatment process(P<0.05).(4)TCM syndrome score:The TCM syndrome scores of the treatment group before and after treatment were(8.60±1.71)points and(3.75±1.37)points respectively;The control group was(8.77±1.87)points and(8.56 ± 1.80)points before and after treatment,In the treatment group was significantly lower than the scores before treatment(P<0.05),The control group had no obvious effect in reducing the scores of TCM syndromes(P>0.05).(5)Laboratory indicators:Serum CRP:The treatment group was(7.66± 1.23)mg/L and(4.98 ± 1.35)mg/L before and after treatment;the control group was(7.31±1.15)mg/L,(5.19±1.25)mg/L before and after treatment,Both groups decreased after treatment compared with before treatment(P<0.05),and there was no statistically significant difference in the decrease between the two groups(P > 0.05).Serum IL-17A:The treatment group was(17.89±2.06)pg/m L and(14.98±1.19)pg/m L before and after treatment;the control group was(17.31 ± 1.64)pg/m L and(15.59 ± 1.24)pg/m L before and after treatment.Two groups after treatment than before treatment decreased(P<0.05),the treatment group decreased more significantly(P<0.05).(6)The clinical efficacy of the two groups:After 8weeks of treatment,the total effective rate in the treatment group was 82.5%,and the total effective rate in the control group was 66.67%.The difference in total effective rate between the two groups was statistically significant(P<0.05).(7)Adverse reactions and safety:In the treatment group,there were 2cases of adverse reactions during the treatment,and the incidence of adverse reactions was 5.00%.In the control group,there were 3 cases of adverse reactions during treatment,and the incidence of adverse reactions was7.69%.There was no statistically significant difference between the two groups(P>0.05),There were no obvious abnormalities in hematuria and liver and kidney functions in the two groups before and after treatment.Conclusion: Fangfengtongshengsan Modified and Subtracted Recipe in the treatment of patients with psoriasis vulgaris has the effect of reducing the area of skin lesions,reducing the severity of skin lesions,and significantly improving clinical performance.It can reduce the levels of serum CRP and serum IL-17A without obvious toxicity side effect. |
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