Clinical Observation Of Shengxue Tongbian Granule In Adjuvant Treatment Of Sepsis With Blood Deficiency And Intestinal Dryness Syndrome

Objective: Objective To observe the clinical efficacy of Shengxue Tongbian granule in the adjuvant treatment of sepsis with blood deficiency and intestinal dryness syndrome,so as to provide a more effective method for the clinical treatment of sepsis.Methods: 64 patients with blood deficiency and intestinal dryness syndrome of sepsis in intensive care unit(ICU)of Hunan hospital of traditional Chinese medicine were randomly divided into treatment group and control group,32 cases in each group.Both groups were given basic Western medicine treatment.The treatment group was treated with Shengxue Tongbian granule(8g / bid,warm water,taken in the morning and after dinner),and the control group was treated with Bifidobacterium Lactobacillus triple viable tablets(4 tablets / bid,taken in the morning and after dinner)Before and after treatment,the improvement of TCM syndrome,the changes of serum TNF-a,IL-10,PCT,CRP,CD4 + percentage and Apache Ⅱ score were compared between the two groups,and the curative effect of TCM syndrome was compared between the two groups.Results: There was no significant difference in age,gender and distribution of primary diseases between the two groups(P > 0.05).After treatment,TCM syndrome,TNF-a,IL-10,PCT,CRP,CD4 + percentage and Apache Ⅱ score of the two groups were significantly improved(P < 0.05).The improvement of TCM symptoms,TNF-a,IL-10,PCT,CRP,CD4 + percentage and Apache Ⅱ score in the treatment group before and after treatment was significantly greater than that in the control group(P <0.05).After treatment,the total score of TCM syndrome in the two groups was significantly lower than that before treatment(P < 0.05),and the total score of TCM syndrome in the treatment group was significantly lower than that in the control group(P < 0.05).The TCM syndrome efficacy and clinical comprehensive efficacy of the treatment group were significantly better than those of the control group(P < 0.05).Conclusion: Shengxue Tongbian granule is superior to Bifidobacterium group in TCM syndrome efficacy and clinical comprehensive efficacy of sepsis patients with blood deficiency and intestinal dryness syndrome,which can be further promoted in clinic.