In this thesis, the evolving history of unconventional biochemical logic system---biocomputing as well as its applications will be introduced. The following chapters will focus on the development of fundamental biocomputing logic gates, including their preliminary noise reduction study and a tentative approach for scaling up the module array of biocomputing logic gates. Then intensive attentions will be put into exploring the biochemical applications such as controllable releasing of reactive oxidative species and injury biosensors with built-in logic. Afterwards, the integration of biocomputing systems with signal responsive materials and responsive bioelectronic interfaces will be discussed, which are expected to act as the potential actuators for the biocomputing systems. |