Study On The Clinical Efficacy Of Treating Chronic Heart Failure Combined With Insomnia Based On The Heart, Brain And Kidney Axis

Purpose:According to tutor professor Zhang Yan accumulated for many years in the clinical work experience benefit heart kidney,invigorate the sedative effect,treatment of chronic heart failure with insomnia is deficiency of heart kidney qi,blood stasis resistance of patients.This paper attempts to find the theoretical basis of the "heart and brain kidney axis" and the clinical efficacy and safety of the treatment of chronic heart failure combined with insomnia from the perspective of "the heart and the kidney axis".It provides a powerful reference value for traditional Chinese medicine to treat chronic heart failure and insomnia.Material and method:All the subjects were patients from the cardiopulmonary K outpatient clinic and ward of Liao Ning province from June 2016 to June 2017.A total of 64 patients were selected to meet the diagnostic criteria of traditional Chinese medicine and western medicine.Among them,64 patients with chronic heart failure combined with insomnia were selected according to the standard of this study,and all the subjects included were randomly assigned to each group(treatment group and control group),with 32 patients in each group.Control group by ACEI,beta blockers,aldosterone receptor antagonist combined treatment,the treatment group in the control group on the basis of using benefit heart kidney,invigorate the circulation of the nerves of traditional Chinese medicine medicinal broth(in Liaoning University Hospital of Traditional Chinese medicine pharmacy configuration,each 100 ml,secondary oral).Four weeks is a course of treatment.Observed before and after treatment the two groups of cardiac function indexes(EF),6 min walking distance,heart failure the curative effect of integral method(Lee's),NT-Pro BNP improvement,insomnia symptom improvement(Pittsburgh sleep quality index scale),Chinese medicine symptom integral,and the basic vital signs of observation of patients during treatment and adverse reactions.Results: 1.During the test,4 subjects lost their compliance,but did not affect the statistical results.2.The improvement of cardiac function index,6min walking distance,nt-probnp level and TCM syndrome differentiation was superior to the control group.3.The effective rate of treatment group was 96.7%,and the control group was 76.7%.The treatment group was better than the control group.4.The treatment group was superior to the control group in the integral of 7 aspects of PSQI.5.During the observation period,all subjects showed no adverse reactions and discomfort and safety.Conclusion: 1.Invigorating heart and kidney,activating blood and tranquilizing Chinese medicine decoction combined with western medicine and western medicine basic treatment for chronic heart failure and insomnia,the subjects are all effective.2.Invigorating the kidney,activating blood and tranquilizing traditional Chinese medicine decoction can obviously improve the TCM symptoms,cardiac function level,6min walking distance,NT-Pro BNP level.Therefore,it can increase the patient's exercise tolerance and improve the patient's cardiac function level,and improve the quality of life of the patients.3.After the test,benefit heart kidney,invigorate the circulation of the nerves of traditional Chinese medicine medicinal both can significantly improve patients with chronic heart failure with insomnia Pittsburgh sleep quality index,improve the symptoms of heart failure in patients with insomnia,this is great news for patients with chronic heart failure,for the long-term prognosis of patients with heart failure have a positive significance.4.Invigorating the heart and kidney,activating blood and tranquilizing Chinese medicine decoction,while improving the clinical efficacy of patients with heart failure and insomnia,there is no obvious or serious side effect.