| Purpose:The purpose of this study is to verify the clinical efficacy of Bushen Huoxue traditional Chinese medicine in the treatment of chronic heart failure by comparing and analyzing the changes of various indicators,and to clarify the theoretical basis of treating chronic heart failure by heart kidney coordination,So as to further provide new ideas and methods for the clinical treatment of chronic heart failure.Material and method:Materials: the subjects of this study were from the 37 clinic of expert clinic on the 6th floor of Affiliated Hospital of Liaoning University of traditional Chinese medicine,and the treatment time was from January 2019 to January 2020.The study was included in 70 patients with coronary heart disease with chronic heart failure(cardiac function grade II or ?),which is characterized by qi deficiency and blood stasis.Methods:70 patients who met the inclusion criteria were randomly divided into control group and experimental group,each group was 35 cases,the control group was treated with conventional western medicine for chronic heart failure,and the experimental group was treated with traditional Chinese medicine for tonifying kidney and activating blood circulation on the basis of the control group,and the treatment course of both groups was 4 weeks.The changes of TCM syndrome score,cardiac function grade,6-minute walking distance,Minnesota quality of life table,NT-proBNP concentration and LVEF value were recorded before and after treatment,and then statistical analysis was conducted by SPSS.During the treatment,the changes of safety indexes and adverse reactions should be monitored closely.Results:1.General information: before treatment,there was no significant difference in gender,age,course of disease and basic diseases between the two groups(P > 0.05).2.TCM syndrome score: before treatment,there was no significant difference in TCM syndrome score between the two groups(P = 0.326);After treatment,the TCM syndrome scores of the two groups were lower than those before treatment,and there was statistical difference between the two groups(P < 0.05);After treatment,the TCM syndrome score of the experimental group was lower than that of the control group,and there was significant difference between the two groups(P < 0.05)3.Cardiac function grading: before treatment,there was no significant difference in cardiac function grading between the two groups(P = 0.801);After treatment,the total effective rate of the experimental group(94.1%)was higher than that of the control group(84.8%),and the difference was statistically significant(P < 0.05).4.6-minute walking distance: before treatment,there was no significant difference in 6-minute walking distance between the two groups(P = 0.980);After treatment,the 6-minute walking distance of the two groups increased compared with that before treatment,and there was significant difference between the two groups(P < 0.05);After treatment,the 6-minute walking distance of the experimental group was increased compared with that of the control group,and there was significant difference between the two groups(P < 0.05).5.Minnesota quality of life table: before treatment,there was no significant difference in the scores of the two groups(P = 0.393);After treatment,the scores of Minnesota quality of life table in the two groups were lower than before treatment,and there was a statistical difference between the two groups(P < 0.05);The scores of Minnesota quality of life table in the experimental group were lower than those in the control group,and there was a statistical difference between the two groups(P < 0.05).6.NT-proBNP concentration: before treatment,there was no significant difference in NT-proBNP concentration between the two groups(P = 0.581);After treatment,the concentration of NT-proBNP in the two groups was lower than that before treatment,and there was significant difference between the two groups(P < 0.05);After treatment,the concentration of NT-proBNP in the experimental group was lower than that in the control group,and the difference between the two groups was statistically significant(P < 0.05).7.LVEF: before treatment,there was no significant difference between the two groups(P =0.465);After treatment,LVEF values of the two groups were increased compared with those before treatment,and there was significant difference between the two groups(P < 0.05);After treatment,the LVEF value of the experimental group was higher than that of the control group,and there was significant difference between the two groups(P < 0.05).Conclusion:1.Based on the theory of heart and kidney,the combination of tonifying kidney and activating blood circulation and Western medicine combined with basic treatment has more obvious clinical effect and can significantly improve the clinical symptoms of patients with chronic heart failure.2.Based on the theory of heart and kidney,the application of Bushen Huoxue herbs can significantly improve the therapeutic indexes of patients with chronic heart failure of qi deficiency and blood stasis type,reduce the concentration of NT-proBNP,increase LVEF,improve the classification of heart function,improve exercise endurance,and gradually improve the quality of life.3.Based on the "heart and kidney theory",it is safe and reliable to use Bushen Huoxue traditional Chinese medicine in the treatment of chronic heart failure,which has a certain value for clinical application. |
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