Observation Of The Clinical Efficacy Of Dingtong Ointment In The Treatment Of Knee Osteoarthritis

Objective:The purpose of this study was to observe the changes of scores before and after the treatment of knee osteoarthritis with Dingtong ointment,to evaluate the therapeutic effect of Dingtong ointment and to evaluate the safety of Dingtong ointment by observing the adverse reactions such as skin allergy.In order to provide the basis for the clinical promotion and further research of Dingtong ointment.Methods:There were 60 patients with knee osteoarthritis who met the inclusion criteria were selected from the outpatient Department of Beijing Traditional Chinese Medicine Hospital Affiliated to Capital Medical University,from December 2016 to December 2018.According to the random number table method,the patients were randomly divided into experimental group(n=30)and control group(n=30).The experimental group was treated with Dingtong ointment(made of honghua danggui zicao zhiruxiang zhimoyao and other herbs)for 6h/days,7 days as a course of treatment.A total of 4 courses of treatment;The control group was treated with futalin latex(provided by Beijing Novartis Pharmaceutical Company)for external use,twice a day,7 days a course of treatment,a total of 4 courses of treatment,WOMAC score,Lysholm score and VAS score were observed and compared before treatment,I week after treatment,2 weeks after treatment,4 weeks after treatment and 3 months after treatment.at the same time,the adverse reactions of the patients were strictly recorded.To study the clinical efficacy and safety of Dingtong ointment in the treatment of degenerative osteoarthropathy of knee joint.Results:At the end of the study,there were 2 cases of shedding in the treatment group and 1 case in the control group,Statistical analysis showed that there was no significant difference in sex,age,course of disease and other baseline data between the two groups(P>0.05).After a week of treatment,There was no significant difference in VAS pain score,WOMAC score and Lysholm score between the two groups(P>0.05).There was no significant difference in VAS score,WOMAC score and Lysholm score before and after treatment(P>0.05),which indicated that Dingtong ointment and futalin in the treatment of knee joint were not significantly different from those before and after treatment(P>0.05).they has the same effect.After two weeks of treatment,There was no significant difference in VAS,WOMAC and Lysholm scores between the two groups(P>0.05),but there was no significant difference in VAS score,WOMAC score and Lysholm score between the two groups before and after treatment(P>0.05).The results showed that the curative effect of Dingtong ointment was still the same as that of futalin in the treatment of knee osteoartlhritis.After 4 weeks of treatment,there were significant differences in VAS score and Lysholm score between the two groups(P<0.05),and there was significant difference between the two groups before and after treatment(P<0.05),and there was significant difference between the two groups before and after treatment.The results showed that the curative effect of Dingtong ointment in the treatment of knee osteoarthritis was remarkable,which was better than that of futalin.After 3 months of follow-up,There was no significant difference in VAS score,WOMAC score and Lysholm score between the two groups(P>0.05),but there was significant difference in VAS score between the two groups before and after treatment(P<0.05).The results showed that the long-term analgesic effect of Dingtong ointment was better than that of futalin in the treatment of knee osteoarthritis.In the aspect of curative effect evaluation,the two groups were evaluated on the basis of WOMAC score,and the curative effect of the two groups was evaluated at the end of the fourth week of treatment.Results the total effective rate was 92.86%and the effective rate was 53.57%in the experimental group and 82.14%and 28.57%in the control group,the total effective rate of the two groups was tested by chi-square test.There was no significant difference between the two groups(P=0.225>0.05),but there was significant difference in the healing rate between the two groups(P=0.014<0.05),which indicated that Dingtong ointment and futalin were effective in the treatment of knee osteoarthritis.In terms of safety,2 cases of skin allergy occurred in the treatment group,of which 1case was caused by the long time of external application of Dingtong ointment,accounting for 6.66%of the total,and 1 case of skin allergy occurred in the control group,accounting for 3.33%of the total.Allergies in both groups improved after withdrawal,There was no significant difference in allergy rate between the two groups(P>0.05).Conclusion:Through research and analysis,it can be concluded that Dingtong ointment is effective in the treatment of knee osteoarthritis,which can effectively relieve knee joint pain,improve knee joint function and improve the quality of life of patients,and the long-term effect is better than that of futalin.The short-term curative effect of Dingtong ointment(within 2 weeks)was similar to that of futalin,but by prolonging the treatment time,the curative effect of Dingtong ointment was obviously better than that of futalin in a relatively long-term time(4 weeks).In terms of relative long-term curative effect(3 months),the analgesic effect of Dingtong ointment was better than that of futalin.In terms of safety,there was no significant difference between Dingtong Ointment and futalin.In short,the long-term efficacy of Dingtong Ointment is relatively significant,and its safety is relatively high,which is worthy of clinical application.