Clinical Efficacy And Safety Evaluation Of External Treatment Of Multiple Verruca Vulgaris With Fire Needle

Objective:1.To objectively evaluate the clinical efficacy and safety of external fire needle therapy for multiple verruca vulgaris through randomized controlled clinical trials.2.To explore the clinical value and popularization of external treatment of multiple verruca vulgaris with fire needle.Method:76 patients with multiple verruca vulgaris diagnosed in outpatient clinic and met the inclusion criteria were selected as the research objects.The patients were randomly divided into treatment group(fire needle injection treatment group)and control group(polymyocyte injection control group),38 cases in each group.The treatment group was treated by repeated needling on the surface of warts.The control group was treated by polymyocyte injection on the bottom of warts once a week for 14 days as a course of treatment.The recurrence of skin lesions was observed for 12 weeks and followed up 2 weeks after drug withdrawal.The size and thickness of target skin lesions,number of skin lesions,tenderness,pain degree and adverse reactions were evaluated and recorded every two weeks.The quality of life(DLQI score),blood routine and liver and kidney function of patients before and after treatment were also evaluated and recorded,so as to demonstrate the clinical efficacy of fire needle therapy for multiple verruca vulgaris,the degree of pain and adverse reactions of patients after injection,the influence on patients' quality of life and treatment safety.Result:1.Clinical efficacy: 12 weeks after treatment,the cure rate of the treatment group was 31% and the effective rate was 66%,while that of the control group was 30% and 57%,P=0.69.There was no significant difference between the two groups(P>0.05).2.Comparison of curative effect of single sign: Compared with before treatment,after 12 weeks of treatment,the scores of four single signs in target lesion size,target lesion thickness,number of lesions and tenderness of the two groups were significantly lower than before treatment,and the difference was statistically significant.(P<0.01).But after 12 weeks of treatment,there was no significant difference between the treatment group and the control group(P > 0.05).3.Pain evaluation of patients during injection: After 12 weeks of treatment,the average pain of patients in the treatment group was 4.7,while that in the control group was 6.1.The average pain of patients in the treatment group was significantly lower than that in the control group(P < 0.01).4.DLQI Score Table: Compared with before treatment,after 12 weeks of treatment,the DLQI scores of the two groups were significantly lower(P < 0.01).However,after 12 weeks of treatment,there was no significant difference in DLQI scores between the treatment group and the control group(P > 0.05).5.Safety evaluation: 2 cases in the treatment group had mild infection at the injection site,and 1 case in the control group had mild infection at the injection site.Conclusion:1.External treatment of multiple verruca vulgaris with fire needle can significantly improve the clinical symptoms and quality of life of patients.2.The pain degree of patients with multiple verruca vulgaris treated with fire needle is significantly lower than that of local injection of polymyocyte.External treatment with fire needle is more acceptable to clinical patients.3.There is no significant difference in the clinical efficacy of external fire needle therapy for multiple verruca vulgaris compared with local injection of polymyocyte,suggesting that external fire needle therapy for multiple verruca vulgaris is effective,safe and easy to operate.It is more suitable for the officers and soldiers who suffer from multiple verruca vulgaris in remote areas lacking of medical treatment and medicines and in wartime harsh environment.