CIMT And Its Correlation With Vitamin D In Obstructive Sleep Apnea-hypopnea Syndrome

Aim:To acknowledge obstructive sleep apnea hypopnea syndrome patients' carotid intima-media thickness and blood vitamin D level,and the relationship between their carotid intima-media thickness,vitamin D and apnea hypopnea index.Material and methods : Use the portable monitor to record the sleep condition of the people reference for the health examination who have snored,been witnessed apnea or had daytime sleepiness.Employ the technique of electrochemiluminescence to test vitamin D level in the blood.The carotid intima media thickness was measured using a high frequency,B-mode ultrasound system with a 5-13 MHZ probe.According to the apnea hypopnea index,divide all the objects of the study into four groups: control group,mild OSAHS group,middle OSAHS group and severe OSAHS group.Compare four groups' intima-media thickness and blood vitamin D level.Analyze the relationship between their carotid intima-media thickness,vitamin D and apnea hypopnea index.And apply multiple linear regression analysis to find the influence factors of carotid intima-media thickness.Results: Comparing to the control group and mild OSAHS group,severe OSAHS group' patients have higher carotid intima-media thickness(0.88±0.15 vs 0.75±0.14;0.88±0.15 vs 0.76±0.14,both p<0.05).Comparing to the control group,middle and severe OSAHS group have lower vitamin D levels(19.06±6.04 vs 22.78±7.40;17.67±4.73 vs 22.78±7.40,both p<0.05).Differences are statistically significant.Spearman relation analysis shows CIMT is positively related to age,AHI,oxygen desaturation index,time duration with oxygen saturation less than 90%,fast blood glucose and insulin resistance index in HOMA-IR(r=0.324,0.293,0.264,0.227,0.282,both p<0.05)and negatively related to the lowest oxygen saturation,the average oxygen saturation,vitamin D(r=-0.199,-0.294,-0.318,both p<0.05).Vitamin D is negatively related to high sensitivity c-reactive protein,body mass index,and AHI(r=-0.183,0.217,-0.266,both p<0.05).After adjusting for the effects of various confounding factors,multiple linear regression analysis displays that CIMT in OSAHS patients is independent related to vitamin D and AHI.Conclusion:The CIMT of OSAHS patients is thick and may increases with its increase of severity.The vitamin D level of OSAHS patients is low and may decreases with its increase of its severity.What's more,vitamin D deficiency may be the dangerous factor that can promote the development of atherosclerosis in OSAHS patients.