Comparison Of The Effectiveness Of Tamsulosin And Solifenacin Monotherapy And Their Combination In The Treatment Of Ureteral Stent Related Symptoms

Objective This study aimed to evaluate the effectiveness of tamsulosin monotherapy for the treatment of ureteral stent-related symptoms(SRSs)and compare it with that of solifenacin monotherapy and combined therapy of tamsulosin and silifenacin.Methods Randomized controlled trials(RCTs),which evaluated the effectiveness of tamsulosin for the treatment of SRSs,were searched from the databases PubMed,EMBASE and the Cochrane Library published up to November 2018.Eight RCTs involving1087 participants were finally included in this meta-analysis.Results The results showed that tamsulosin monotherapy could significantly decrease the urinary symptoms [mean difference(MD)–7.56,95% confidence interval(CI)(–11.47,–3.65),P=0.0001]and body pain [MD –5.25,95% CI(–8.03,–2.46),P=0.0002],and improve the sexual performance [MD –1.06,95% CI(–1.89,–0.24),P=0.01] compared with the control group.Moreover,there was no significant difference between tamsulosin monotherapy and solifenacin monotherapy in all outcomes except for significantly better sexual performance in solifenacin group [MD 0.29,95% CI(0.06,0.51),P=0.01].In addition,the effectiveness of combined therapy of tamsulosin and solifenacin was not superior to that of tamsulosin monotherapy.Conclusion Our study demonstrated that tamsulosin monotherapy was effective for the treatment of patients with SRSs;evident superiority could not be found for therapy of tamsulosin and solifenacin combined.