Effect Of Hypothermic Perfusion On Phacoemulsification In Cataract Patients Complicated With Uveitis

Objective To evaluate the effectiveness and safety of hypothermic perfusion in the phacoemulsification of cataract caused by uveitis.Methods This was a prospective,randomised,controlled clinical trial.One hundred and six patients with uveitis-associated cataract underwent phacoemulsification with perfusion fluid temperature at 4?(treatment group)or 24?(control group)at the First Affiliated Hospital of Chongqing Medical University from December 2017 to May 2019.Anterior chamber inflammation grade,corneal endothelial cell count,corneal thickness,macular fovea thickness,and intraocular pressure(IOP)were observed on the 1st day and 7th day after operation.Results The aqueous flare score was 0.83±0.76 in the 4? group,which was lower than that in the 24? group(1.51±1.02,P = 0.006)on the first day after operation.The aqueous cells score was lower in the 4?group(0.17±0.38)than that in the 24? group(0.62±0.94,P = 0.025).The mean corneal thickness of incision in the 4? group(907.66±85.37 ?m)was thinner than that in the 24? group(963.75±103.81 ?m,P = 0.005).Corneal endothelial cells density,macular fovea thickness,or percentage of transiently increased IOP showed no difference between the two groups(P > 0.05).There was no significant difference in all the main outcome parameters between the two groups on the 7th day after operation(P >0.05).Conclusion Hypothermic perfusion in the phacoemulsification of uveitis-associated cataract is safe,and it can effectively inhibit anterior chamber inflammation and reduce the incisional corneal edema in the early postoperative stage.