Significance Of Serum Pepsinogen,Gastrin-17 And Helicobacter Pylori Infection In Reflux Esophagitis

Objective We explored the significance of serum pepsinogen,gastrin,and Helicobacter pylori infections in reflux esophagitis,with a view to providing assistance in the diagnosis and treatment and effective prevention of reflux esophagitis in clinical work,as well as related research in the future Provide scientific evidence.Methods All the studies were on the outpatients of the affiliated hospital of Inner Mongolia Medical University.60 patients with endoscopic diagnosis of RE,and 42 patients with NERD who had no organic lesions but had reflux symptoms（Gerd Q score≥8）were selected.40healthy patients who had no reflux symptoms at the same time and had no abnormalities after endoscopy were selected as the control group.All enrolled subjects had complete endoscopy,serum gastric function measurement,and C¹⁴breath test.Compare the levels of PG I,PG II,PGR,G-17 and HP infection among groups;patients in RE group were classified according to the Los Angeles classification method:26 cases of LA-A grade,23 cases of LA-B grade,11cases of LA-C/D grade,compared the PG I,PG II,PGR,G-17 levels and HP infection among RE patients with different grades;all subjects were grouped according to HP positive or HP negative:61 cases in HP-positive group,81 cases in HP-negative group.The levels of PG I,PG II,PGR,and G-17 were compared between the two groups.SPSS 23.0 statistical software was used.The qualitative data is expressed as a percentage（N%）,and the chi-square test is used for comparison;Quantitative data are expressed as mean±standard deviation（?x±S）.The comparison of quantitative data between multiple groups uses analysis of variance.The pairwise comparison between multiple groups uses the LSD method.The comparison of quantitative indicators between two groups uses two independent sample t tests.The difference was statistically significant at P<0.05.Results（1）G-17 level:RE group（4.82±5.844）,NERD group（5.98±7.031）,control group（4.58±3.644）,there was no significant difference between the three groups（P>0.05）;（2）PG I level:The RE group（108.75±59.118）,the NERD group（107.12±42.898）,and the control group（134.9±71.759）.Pairwise comparison between the three groups found that PG I was reduced in the RE group and the NERD group,and the differences were statistically significant.（P<0.05）;（3）PG II level:RE group（7.55±7.173）,NERD group（6.98±3.254）,control group（9.88±5.626）,analysis found that PG II level in NERD group was lower than the control group,the difference was statistically significant Significance（P<0.05）;（4）PGR value:RE group（18.36±10.645）,NERD group（16.69±5.743）,control group（13.98±3.491）,PGR was different between the three groups,and the difference was statistically significant（P<0.05）,between the three groups Pairwise comparison,the PGR in the RE group was higher than that in the control group,the difference was statistically significant（P<0.05）;（5）HP positive rate:41.7%in the RE group,40.5%in the NERD group,and 47.5%in the control group.The difference was not statistically significant（P>0.05）.（6）There was no statistically significant difference in the overall comparison of various indicators between RE patients with different grades.After comparison,it was found that the level of PG II in patients with LA-A was higher than that in patients with LA-B.The difference was statistically significant（P<0.05）;（7）There are differences between G-17,PG I,PG II and other indicators when HP is positive or negative,and the difference is statistically significant（P<0.05）.Conclusion:（1）Patients with RE have lower PG I levels and higher PGR levels.It is speculated that RE patients have lower PG II levels.The severity of RE patients may be inversely related to PG II levels.Test with PG to improve the detection rate of RE;（2）The occurrence and severity of RE are not related to G-17 level and HP infection;（3）PGR level change does not reflect the severity of RE disease;（4）The levels of PG I and PG II in NERD patients decreased,and it is speculated that there is also some mucosal damage in NERD;（5）The levels of G-17 and PG are related to HP infection.After HP infection,the levels of G-17,PG I,and PG II will increase,so HP should also be considered when studying diseases related to G-17 and PG The impact of infection.