| Objective:Analysis of serum pepsinogen(PG),Pepsin ratio(PGR),Gastrin-17(G-17),and Helicobacter Pylori(Hp)Quantitative detection and correlation between benign and malignant gastric diseases,and explore the value of the above indicators in the diagnosis of atrophic gastritis and gastric cancer.Methods:The population was collected from the affiliated hospital of Beihua University from May 2017 to December 2018.According to the results of conventional gastroscope and histopathology,combined with inclusion criteria and exclusion criteria,120 patients were selected and divided into control group(30cases),gastric ulcer group(30 cases),atrophic gastritis group(30 cases),and gastric cancer group.(30 cases),including 65 male patients and 55 female patients;aged 26-75 years,mean 53.11±9.85 years old.Serum PGI and PGII levels were measured by chemiluminescence immunoassay and PGR values were calculated.Serum G-17 levels were measured by enzyme-linked immunosorbent assay(ELISA),and Hp infection was qualitatively and quantitatively detected by 13C-urea breath test.By analyzing the relationship between the above-mentioned test indicators and benign and malignant gastric diseases,the value of the above-mentioned test indicators for the diagnosis of atrophic gastritis and gastric cancer was evaluated.Result:1.Serum PGI levels in the control group,atrophic gastritis group and gastric cancer group were progressively decreased,and the difference between the two groups was statistically significant(control group compared with atrophic gastritis group:Z=2.66,P<0.05;control group and Gastric cancer group comparison: Z = 5.422,P<0.01;atrophic gastritis group compared with gastric cancer group: Z = 2.76,P<0.01).2.Compared with the control group,atrophic gastritis group and gastric cancer group,the serum PGII level in the gastric ulcer group was significantly increased,the difference was statistically significant(P<0.01);the control group,the atrophic gastritis group,the gastric cancer group PGII level gradually Increased,but the difference between the groups was not statistically significant(P>0.05).3.The PGR values of the four groups were progressively decreased,and the difference was statistically significant(F=20.95,P<0.01).The difference between the two groups was statistically significant(The control group was compared with the atrophic gastritis group: F=2.03,P<0.01;the control group compared with the gastric cancer group: F=5.86,P<0.01;the atrophic gastritis group compared with the gastric cancer group: F=1.21,P<0.01).4.Compared with the gastric cancer group,G-17 was decreased in the atrophic gastritis group,and the difference was statistically significant(compared with gastric cancer group and atrophic gastritis group: Z=-3.28,P<0.01).5.The infection rate of Hp in the control group,gastric ulcer group,atrophic gastritis group and gastric cancer group increased gradually.The Hp infection rate of the control group was the lowest(50.00%),and the gastric cancer group had the highest infection rate(80.00%),but each group There was no significant difference between the two(?2=6.593,P=0.086).Serum PGII level,Hp positive group was higher than Hp negative group,the difference was statistically significant(Z=-2.96,P<0.01);PGR value,Hp positive group was lower than Hp negative group,the difference was statistically significant(Z =-2.81,P <0.01).Quantitative grading comparison of Hp infection showed that the levels of serum PGII in Hp(+)and Hp(++)groups were higher than those in Hp(-)group,and the difference was statistically significant(Hp(-)group and Hp(+).Comparison:Z=-2.61,P<0.05;Hp(-)group and Hp(++): Z=-2.50,P<0.05);compared with Hp(+)group,Hp(-)group PGR level increased High,the difference was statistically significant(Z = 2.86,P < 0.05).6.Serum PG I,PGR,G-17 combined with Hp infection in the diagnosis of atrophic gastritis,gastric cancer ROC curve area,sensitivity,specificity were 0.882,90.5%,72.2%;0.932,95.8%,79.6%;and separate detection In comparison,the combined detection sensitivity and specificity are higher.Conclusion:1.With the severity of gastric mucosal lesions,serum PGI levels and PGR values decreased,Hp infection increased PGII levels,PGR decreased;serum G-17 levels in atrophic gastritis group decreased,and serum G-17 levels in gastric cancer group increased.2.The sensitivity and specificity of serum PGI,PGR,G-17 combined with Hp infection detection were higher than those of the single test.Combined detection can improve the detection rate of gastric cancer and atrophic gastritis. |
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