Influence And Clinical Value Of Helicobacter Pylori Eradication On Serum Level Of Gastrin-17and Pepsinogen In Patients With Helicobacter Pylori Related Gastric Disease

Objective:By observing the serum level of gastrin-17and pepsingen in patients withhelicobacter pylori related gastric disease(gastric ulcer, duodenal ulcer, chronicatrophic gastritis), and observing the change in serum gastrin-17and pepsingenbefore and after the therapy of Helicobacter pylori eradication，to see the level ofSerum gastrin-17and pepsingen in different gastric disease associated withHelicobacter pylori,analyze the infulence of helicobacter pylori infection in serumgastrin-17and pepsingen to gastric disease and investgate the influence and clinicalvalue of Helicobacter pylori eradication on serum level of gastrin-17and pepsinogenin patients with Helicobacter pylori related gastric disease.Method:Select the patients diagnosed by gastroscope as gastric ulcer, duodenal ulcer,chronic atrophic gastritis as while as accorded with the inclusion criteria as theobservation group，the totual number is451.at the same time choose non-atrophicgastritis or normal patient151cases as control group which also meet the criteria ofhelicobacter pylori negative and have detected serum gastrin-17and pepsingen. serumH.pylor antibody IgG、gastrin-17and pepsingen were also detected in the observationgroup while the gastroscopy. with H. pylori-positive patients were given the therapyof helicobacter pylori eradication including PPI，two kinds of antibiotic, the standardof bismuth，The results of Helicobacter pylori eradication was assessed by13-UBTafter4weeks therapy and without anyother treatment during the time。At the sametime,detection of serum serum gastrin-17and pepsingen was also carried respectivelyto observe the variation of concentration in serum gastrin-17and pepsingen after theHelicobacter pylori eradication therapy. all the data were analyzed by SPSS17.0software for statistical analysis in this study, the rate were expressed by percentage,while the comparison between the rate used chi-square test; The average of thesample expressed by average±standard (x+s)，and t-test was used to compare the average of the sample，and P <0.05means the difference of statistically significant,P values taken the bidirectional.Results：1.The rates of H. pylori infection in gastric ulcer, duodenal ulcer and chronicatrophic gastritis respectively were88.6%,90.1%,79.3%, no significant differencesbetween gastric ulcer and duodenal ulcer, but the atrophic gastritis group is lowerthan gastric duodenal ulcer group.2. the total rate of successful helicobacter pylori eradication therapy inobservation group was88.1%, and the rate of duodenal ulcer、gastric ulcer、chronicatrophic gastrit is respectively is94.9%、89.3%and78.9%. no significant differencebetween the gastric ulcer and duodenal ulcer, but the rate in gastric and duodenal ulceris higher than atrophic gastritis group.3. the level of gastrin-17in gastric ulcer、duodenal ulcer、control group andchronic atrophic gastritis group is declined in turns. The serum PGI and PGII、PGI/IIin duodenal ulcer and gastric ulcer group were increased compared with the cont-rol group, and the degree of PG I rised more than PGII. PGI and PGI/II inatrophic gastritis group is lower than the control group, but no obvious difference wasfound between PGII in atrophic gastritis group.4. The serum level of G17in Helicobacter pylori infection is higher thanHelicobacter pylori uninfected group. And the serum PGI and PGII in Helicobacterpylori infection group is also higher in gastric ulcer, duodenal ulcer than uninfectedgroup， while the PGI/II is lower.There is no obvious different in PGI betweenHelicobacter pylori infection and uninfection in atrophic gastritis group. But PGII inatrophic gastritis with Helicobacter pylori infection group is higher than uninfectedgroup and PGI/II is lower in helicobacter pylori infection group than in the uninfectedgroup.5. level of G17were significantly decreas in the successful helicobacter pylorieradication group after therpy of eradica-tion.But no obvious change between Helicobacter pylori eradication failuregroup before and after the treatment. 6. PGI after successfully helicobacter pylori eradication in duodenal ulcer,gastric ulcer group were lower than before eradication，but no obvious change ineradication failure group and atrophic gastritis group。 PGII after successfullyhelicobacter pylori eradication in duodenal ulcer, gastric ulcer and atrophic gastritisgroup were significantly lower than before eradication, while no obvious change inthe eradication of failure group. PGI/PGII is higher in the success of the eradicationgroup both in duodenal ulcer, gastric ulcer and atrophic gastritis group than failuregroup，but no obvious change in the eradication of failure.Conclusions：1. The rate of helicobacter pylori in gastric ulcer, duodenal ulcer and chronicatrophic gastritis group was high.2. The totual success rate of helicobacter pylori eradication conclude containsPPI+two kinds of antibiotic, the standard of bismuth，to gastric ulcer, duodenal ulcerand atrophic gas-tritis group, is above80%, almost achieve the helicobacter pylori eradicationgoals。3. the level of Serum gastrin-17and pepsinogen is significant differences ingastric ulcer, duodenal ulcer, chronic atrophic gastritis，so Serum gastrin-17andpepsinogen can be used as an index of gastric mucosa serological detection.4. Serum gastrin-17and pepsinogen could appear recovery change aftersuccessful helicobacter pylori eradication therapy in patients of gastric ulcer、duodenal ulcer and atrophic gastritis. This serum maker may be used as a reliablemarker to evaluate the helicobacter pylori eradication。...