Clinical Significance Of Serum Gastrin,pepsinogen And Helicobacter Pylori In Gastric Polypoid Lesions

OBJECTIVE: To study the clinical significance of serum gastrin,pepsinogen and Helicobacter pylori and new ABC method for gastric polypoid lesions,to judge the early changes of gastric mucosal function,and provide further scientific theory for the treatment of gastric polypoid lesions.Methods: Clinical case data of one hundred and sixty-two inpatients,from Gastroenterology First Affiliated Hospital of Nanhua University between January 1,2016 to December 31,2016,were analyzed.At the same time,fifty-four healthy people were selected as the control group.The positive rate of Helicobacter pylori infection,gastrin-17 and pepsinogen difference between the experimental group and the control group were compared statistically significant or not.According to the number of polypoid lesions in one hundred and sixty-two polypoid lesions,the sex,age,Helicobacter pylori infection rate,gastrin-17 and pepsinogen were analyzed statistically significant or not.One hundred and sixty-two patients were divided into three groups according to the "New ABC" gastric cancer screening method,and the risk of carcinogenesis was evaluated.Results: There was no significant difference in age,PGII and PGR between the experimental group and the control group(P >0.05).There was significant difference in sex,HP infection positive rate,serum PGI and G-17 in the polypoid lesion group compared with the control group(P<0.05).There was significant difference in age,the Hp positive infection rate,the PGI and the G-17 among the single polypoid lesion group,the multiple polypoid lesion group and the control group(P <0.05).There was no statistically significant difference in sex among them(P >0.05).There were significant differences in the Hp infection rate,serum PGI,G-17 among different pathological types of 105 cases of single polypoid lesions(P<0.05).There was no significant difference in age and sex among them(P>0.05).There was no significant difference in age,sex and number among ABC three groups(P>0.05).There was significant difference in Hp infection rate(P < 0.05).There was significant difference in polyp cancer rate among ABC three groups(P <0.05)? Conclusion: 1.Patients of gastric polypoid lesions has abnormal gastric function,and its formation is associated with Hp infection;2.The risk of gastric polypoid lesions to be cancer may be associated with low PGI,high G17.