Relationship Of Serum Albumin With Magnesium And Chronic Heart Failure In The Elderly

Objective:Chronic heart failure(CHF)typically develops as the final stage in a range of cardiovascular diseases,which is based on various heart diseases,and the main manifestation is the decrease of the heart filling or ejection function.In the elderly,the incidence of heart failure has not declined during 2 decades.Serum serum albumin and magnesium have received increasing attention for their potential effect in the elderly.However,rarely research reports the relationship between these nutrients and the risk of CHF.This study proposes to explore the relationship between serum albumin with magnesium and CHF,in order to identify the elderly with heart failure risk.Methods:Atotal of 107 elderly patients with CHF who were hospitalized and treated in our hospital from March 2017 to March 2018 were enrolled,and 91 cases in health people during the same period were enrolled as control group.General clinical data of the patients were collected and compared,such as age,gender,hypertension,coronary heart disease,diabetes,smocking,height,weight,N-terminal pro-B-type natriuretic peptide(NT-ProBNP),left ventricular ejection fraction(LVEF),and serum nutrients(total cholesterol,triglyceride,albumin,serum potassium,serum sodium,serum calcium,serum magnesium and serum phosphorus).The prognostic correlation between serum magnesium and CHF was further explored through follow-up studies.Statistical analysis was performed using SPSS 24.0 statistical software.Qualitative data were tested by?~2 test,quantitative data were tested by t test or Mann-Whitney U test.Variance was used to compare among groups.Logistic binary regression analysis was used to analyze the risk factors of CHF.The test level was P<0.05 with statistical significance.Results:1.A total of 198 subjects were included in the study,including 98 males and 100 females,with a median age of 75 years(65-106 years).Compared with the control group,patients in the CHF group were older.Meanwhile,the levels of total cholesterol,albumin,serum sodium,serum calcium and serum magnesium of CHF group were lower(P<0.05).2.Multivariate logistic regression analysis showed the advanced age(OR=3.306,P<0.05),hypoalbuminemia(OR=0.418,P<0.05)and hypomagnesemia(OR=0.681,P<0.05)were independent risk factors of chronic heart failure after adjusting for multiple confounding factors such as total cholesterol,sodium and calcium.3.The albumin level of heart failure group was significantly lower than that of control group[(36.40 vs 40.20)g/L,P<0.05].In the heart failure group,41(38%)patients had hypoalbuminemia.In the control group,only 14(15%)patients had hypoalbuminemia.The difference was statistically significant(P<0.05).4.The level of serum magnesium in the heart failure group was significantly lower than that in the control group[(0.90±0.13 vs 0.97±0.72)mmol/L,P<0.05].In the heart failure group,13(12%)patients had hypomagnesemia.In the control group,only one(1%)patient had hypomagnesemia.The difference was statistically significant(P<0.05).5.With the degree of chronic heart failure increases,the serum magnesium levels decreased gradually.In the elderly CHF patients,people with hypomagnesemia showed significant higher NT-proBNP and lower LVEF levels than those without hypomagnesemia[(5150.00 vs 2002.50)ng/L,(41%vs 53%);all P values were<0.05].At the same time,the readmission and mortality rates were higher than those without hypomagnesemia[(61.54%vs 26.60%)ng/L,(23.08%vs 5.32%);all P values were<0.05].Conclusions:Hypoalbuminemia and hypomagnesemia are independent risk factors for CHF in the elderly;the level of serum albumin and magnesium in patients with CHF are lower than those in patients without CHF;the elderly patients with chronic heart failure and hypomagnesemia tend to have poor cardiac function and prognosis.