Correlation Between Homocysteine And Cardiovascular Disease In Chronic Kidney Disease

Objective: Mainly explore the correlation between plasma homocysteine(Hcy)value and cardiovascular disease(CVD)in patients with chronic kidney disease(CKD),explore new risk factors based on traditional risk factors,and reduce the heart of CKD patients as much as possible Occurrence of vascular complications,reducing clinical mortalityMethods: A retrospective analysis of a total of 90 cases meeting the inclusion criteria in the Department of Nephrology and Cardiology of our hospital from January 2019 to December 2019,which were divided into the simple CKD group 30 cases,the pure CVD group 30 cases,and the CKD combined CVD group 30 cases.There were 30 healthy people in the hospital physical examination center.As a healthy control group,a total of 120 cases.Analysis of age,gender,systolic blood pressure,diastolic blood pressure,blood glucose,hemoglobin(GHb),triglyceride(TG),total cholesterol(TC),low density lipoprotein(LDL-C),high density lipoprotein(HDL-C),creatinine(Cr),Hcy and other clinical data to clarify the correlation between blood Hcy and CKD cardiovascular disease.Use spss22.0 software to sort the collected clinical data and analyze it with statistical methods.Results: Whether with or without cardiovascular disease,CKD patients had elevated plasma homocysteine levels,which was statistically significant compared with the healthy control group(P <0.01).hyperhomocysteinemia also existed in the simple CVD group.The differences between the two groups were statistically significant(P <0.01).The plasma Hcy level in the CKD combined with CVD group was higher than that in the simple CKD group,and the difference was statistically significant(P <0.01).The plasma Hcy in the CKD combined with CVD group was higher than that in simple CVD group,the difference was statistically significant(P <0.05).In the comparison of other risk factors in the four groups,there was a difference in Cr and HDL-C(P <0.05).In the analysis of the difference in Cr between the groups,CKD was higher than healthy regardless of whether or not CKD was associated with cardiovascular disease.The difference between the control group and the CVD group was statistically significant(P<0.01),and the Cr value of the CKD combined CVD group was higher than that of the CKD group,and the difference was statistically significant(P <0.01).In the analysis of the differences in HDL-C between the groups,the plasma HDL-C value was lower than that of the healthy control group with or without cardiovascular disease in the CKD group,and the difference was statistically significant(P <0.05).In the age analysis of each group,the difference was not statistically significant(P> 0.05).In the gender qualitative analysis of the CKD combined CVD group and the CKD group,the difference was not statistically significant(P> 0.05).In the logistic correlation analysis of various factors related to cardiovascular disease in Hcy and CKD,Hcy and Cr were risk factors for cardiovascular disease in CKD patients,and the difference was statistically significant(P <0.05).In the ROC curve of Hcy predicting cardiovascular disease in CKD patients,the AUC value of Hcy was 0.715,and the difference was statistically significant(P <0.01).Conclusion: Regardless of the presence or absence of cardiovascular disease in patients with CKD,hyperhomocysteinemia is common;hyperhomocysteinemia is also common in patients with CVD;plasma Hcy levels in patients with CKD and CVD are higher than those in patients with CKD or patients with CVD alone.Plasma Hcy and Cr are risk factors for patients with CKD and CVD.Increased plasma Hcy can predict the occurrence of cardiovascular disease in CKD patients to a certain extent.